ras homolog family member U

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
G1/S transition of mitotic cell cycle [GO:0000082],
endocytosis [GO:0006897],
cytoskeleton organization [GO:0007010],
regulation of cell shape [GO:0008360],
cell migration [GO:0016477],
Rac protein signal transduction [GO:0016601],
cytokine-mediated signaling pathway [GO:0019221],
cell projection assembly [GO:0030031],
Cdc42 protein signal transduction [GO:0032488],
regulation of small GTPase mediated signal transduction [GO:0051056],
positive regulation of protein targeting to mitochondrion [GO:1903955],
small GTPase mediated signal transduction [GO:0007264],
actin cytoskeleton organization [GO:0030036],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],

Cellular Component:
Golgi membrane [GO:0000139],
podosome [GO:0002102],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
intracellular [GO:0005622],
Golgi apparatus [GO:0005794],
membrane [GO:0016020],
cell junction [GO:0030054],