RHOH

ras homolog family member H

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2, Li-Fraumeni Human YES

GO terms:

Biological Process:
regulation of transcription, DNA-templated [GO:0006355],
actin filament organization [GO:0007015],
small GTPase mediated signal transduction [GO:0007264],
motor neuron axon guidance [GO:0008045],
regulation of cell shape [GO:0008360],
Rac protein signal transduction [GO:0016601],
cell projection assembly [GO:0030031],
actin cytoskeleton organization [GO:0030036],
T cell differentiation [GO:0030217],
cortical cytoskeleton organization [GO:0030865],
regulation of actin cytoskeleton organization [GO:0032956],
negative regulation of kinase activity [GO:0033673],
negative regulation of GTPase activity [GO:0034260],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
engulfment of apoptotic cell [GO:0043652],
mast cell activation [GO:0045576],
positive regulation of T cell differentiation [GO:0045582],
regulation of small GTPase mediated signal transduction [GO:0051056],
regulation of neutrophil migration [GO:1902622],

Molecular Function:
GTPase activity [GO:0003924],
GTPase inhibitor activity [GO:0005095],
protein binding [GO:0005515],
GTP binding [GO:0005525],
Rho GTPase binding [GO:0017048],
kinase inhibitor activity [GO:0019210],
protein kinase binding [GO:0019901],
nucleotide binding [GO:0000166],

Cellular Component:
immunological synapse [GO:0001772],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
cell cortex [GO:0005938],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],
intracellular membrane-bounded organelle [GO:0043231],
intracellular [GO:0005622],
membrane [GO:0016020],