RHOB

ras homolog family member B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
31148378 MRC-5 Human YES
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
mitotic cytokinesis [GO:0000281],
angiogenesis [GO:0001525],
intracellular protein transport [GO:0006886],
apoptotic process [GO:0006915],
actin filament organization [GO:0007015],
cell adhesion [GO:0007155],
G-protein coupled receptor signaling pathway [GO:0007186],
Rho protein signal transduction [GO:0007266],
endosome to lysosome transport [GO:0008333],
regulation of cell shape [GO:0008360],
positive regulation of endothelial cell migration [GO:0010595],
cell migration [GO:0016477],
actin cytoskeleton organization [GO:0030036],
cell differentiation [GO:0030154],
regulation of cell migration [GO:0030334],
negative regulation of cell migration [GO:0030336],
cortical cytoskeleton organization [GO:0030865],
regulation of actin cytoskeleton organization [GO:0032956],
positive regulation of apoptotic process [GO:0043065],
positive regulation of angiogenesis [GO:0045766],
negative regulation of cell cycle [GO:0045786],
regulation of small GTPase mediated signal transduction [GO:0051056],
endothelial tube morphogenesis [GO:0061154],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to ionizing radiation [GO:0071479],
small GTPase mediated signal transduction [GO:0007264],
multicellular organism development [GO:0007275],
protein transport [GO:0015031],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
GDP binding [GO:0019003],
protein kinase binding [GO:0019901],
nucleotide binding [GO:0000166],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
early endosome [GO:0005769],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cell cortex [GO:0005938],
endosome membrane [GO:0010008],
cytoplasmic vesicle [GO:0031410],
late endosome membrane [GO:0031902],
cleavage furrow [GO:0032154],
cell projection [GO:0042995],
intracellular membrane-bounded organelle [GO:0043231],
extracellular exosome [GO:0070062],
intracellular [GO:0005622],
endosome [GO:0005768],
late endosome [GO:0005770],
membrane [GO:0016020],