RHOA

ras homolog family member A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
17658517 PC-3 Human NO
21273559 HUVEC Aorta Human, mouse NO
31945054 IMR-90 Human YES

GO terms:

Biological Process:
response to hypoxia [GO:0001666],
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure [GO:0001998],
alpha-beta T cell lineage commitment [GO:0002363],
regulation of systemic arterial blood pressure by endothelin [GO:0003100],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
actin filament organization [GO:0007015],
cell-matrix adhesion [GO:0007160],
transforming growth factor beta receptor signaling pathway [GO:0007179],
G-protein coupled receptor signaling pathway [GO:0007186],
Rho protein signal transduction [GO:0007266],
skeletal muscle tissue development [GO:0007519],
regulation of cell shape [GO:0008360],
response to mechanical stimulus [GO:0009612],
response to glucose [GO:0009749],
negative regulation of cell-substrate adhesion [GO:0010812],
viral process [GO:0016032],
cell migration [GO:0016477],
protein deubiquitination [GO:0016579],
substantia nigra development [GO:0021762],
cerebral cortex cell migration [GO:0021795],
forebrain radial glial cell differentiation [GO:0021861],
actin cytoskeleton organization [GO:0030036],
positive regulation of cell growth [GO:0030307],
regulation of cell migration [GO:0030334],
androgen receptor signaling pathway [GO:0030521],
positive regulation of actin filament polymerization [GO:0030838],
cortical cytoskeleton organization [GO:0030865],
stress-activated protein kinase signaling cascade [GO:0031098],
cytoplasmic microtubule organization [GO:0031122],
actin cytoskeleton reorganization [GO:0031532],
positive regulation of cytokinesis [GO:0032467],
regulation of actin cytoskeleton organization [GO:0032956],
negative regulation of intracellular steroid hormone receptor signaling pathway [GO:0033144],
regulation of osteoblast proliferation [GO:0033688],
cell junction assembly [GO:0034329],
substrate adhesion-dependent cell spreading [GO:0034446],
Roundabout signaling pathway [GO:0035385],
cleavage furrow formation [GO:0036089],
apolipoprotein A-I-mediated signaling pathway [GO:0038027],
odontogenesis [GO:0042476],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
stress fiber assembly [GO:0043149],
response to amino acid [GO:0043200],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
apical junction assembly [GO:0043297],
neutrophil degranulation [GO:0043312],
beta selection [GO:0043366],
negative regulation of neuron apoptotic process [GO:0043524],
positive regulation of neuron apoptotic process [GO:0043525],
endothelial cell migration [GO:0043542],
ossification involved in bone maturation [GO:0043931],
wound healing, spreading of cells [GO:0044319],
establishment of epithelial cell apical/basal polarity [GO:0045198],
response to ethanol [GO:0045471],
positive regulation of neuron differentiation [GO:0045666],
positive regulation of translation [GO:0045727],
negative regulation of cell size [GO:0045792],
GTP metabolic process [GO:0046039],
positive regulation of alpha-beta T cell differentiation [GO:0046638],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
ephrin receptor signaling pathway [GO:0048013],
phosphatidylinositol-mediated signaling [GO:0048015],
neuron projection morphogenesis [GO:0048812],
negative regulation of axonogenesis [GO:0050771],
positive regulation of axonogenesis [GO:0050772],
regulation of dendrite development [GO:0050773],
negative chemotaxis [GO:0050919],
regulation of small GTPase mediated signal transduction [GO:0051056],
response to glucocorticoid [GO:0051384],
positive regulation of stress fiber assembly [GO:0051496],
regulation of focal adhesion assembly [GO:0051893],
regulation of calcium ion transport [GO:0051924],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
positive regulation of lipase activity [GO:0060193],
trabecula morphogenesis [GO:0061383],
regulation of microtubule cytoskeleton organization [GO:0070507],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to cytokine stimulus [GO:0071345],
positive regulation of podosome assembly [GO:0071803],
positive regulation of protein serine/threonine kinase activity [GO:0071902],
negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051],
mitotic spindle assembly [GO:0090307],
negative regulation of oxidative phosphorylation [GO:0090324],
endothelial tube lumen extension [GO:0097498],
positive regulation of NIK/NF-kappaB signaling [GO:1901224],
skeletal muscle satellite cell migration [GO:1902766],
negative regulation of reactive oxygen species biosynthetic process [GO:1903427],
mitotic cleavage furrow formation [GO:1903673],
positive regulation of vascular smooth muscle contraction [GO:1904695],
positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996],
regulation of modification of postsynaptic actin cytoskeleton [GO:1905274],
cellular response to chemokine [GO:1990869],
regulation of cell motility [GO:2000145],
regulation of neural precursor cell proliferation [GO:2000177],
positive regulation of T cell migration [GO:2000406],
cell morphogenesis [GO:0000902],
cytoskeleton organization [GO:0007010],
cell cycle [GO:0007049],
cell adhesion [GO:0007155],
integrin-mediated signaling pathway [GO:0007229],
small GTPase mediated signal transduction [GO:0007264],
regulation of neuron projection development [GO:0010975],
negative regulation of neuron projection development [GO:0010977],
cell differentiation [GO:0030154],
response to drug [GO:0042493],
negative regulation of neuron differentiation [GO:0045665],
positive regulation of smooth muscle contraction [GO:0045987],
cell division [GO:0051301],
negative regulation of cell death [GO:0060548],
regulation of modification of synaptic structure [GO:1905244],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
myosin binding [GO:0017022],
GDP binding [GO:0019003],
protein kinase binding [GO:0019901],
protein domain specific binding [GO:0019904],
Rho GDP-dissociation inhibitor binding [GO:0051022],
nucleotide binding [GO:0000166],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
endosome [GO:0005768],
endoplasmic reticulum membrane [GO:0005789],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cell cortex [GO:0005938],
lamellipodium [GO:0030027],
cell junction [GO:0030054],
axon [GO:0030424],
midbody [GO:0030496],
secretory granule membrane [GO:0030667],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
cytoplasmic vesicle [GO:0031410],
vesicle [GO:0031982],
cleavage furrow [GO:0032154],
ruffle membrane [GO:0032587],
cell projection [GO:0042995],
dendritic spine [GO:0043197],
intracellular membrane-bounded organelle [GO:0043231],
apical junction complex [GO:0043296],
extracellular exosome [GO:0070062],
cell periphery [GO:0071944],
postsynapse [GO:0098794],
glutamatergic synapse [GO:0098978],
ficolin-1-rich granule membrane [GO:0101003],
intracellular [GO:0005622],
mitochondrion [GO:0005739],
membrane [GO:0016020],