BCL2 antagonist/killer 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C-85 Human NO
31148378 MRC-5 Human YES
31799499 IMR-90 Liver Human, mouse NO
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
B cell homeostasis [GO:0001782],
B cell apoptotic process [GO:0001783],
release of cytochrome c from mitochondria [GO:0001836],
blood vessel remodeling [GO:0001974],
myeloid cell homeostasis [GO:0002262],
B cell negative selection [GO:0002352],
apoptotic process [GO:0006915],
brain development [GO:0007420],
aging [GO:0007568],
mitochondrial fusion [GO:0008053],
cell proliferation [GO:0008283],
negative regulation of cell proliferation [GO:0008285],
intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630],
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [GO:0008635],
response to fungus [GO:0009620],
response to mycotoxin [GO:0010046],
response to UV-C [GO:0010225],
establishment or maintenance of transmembrane electrochemical gradient [GO:0010248],
response to gamma radiation [GO:0010332],
positive regulation of calcium ion transport into cytosol [GO:0010524],
negative regulation of gene expression [GO:0010629],
response to organic cyclic compound [GO:0014070],
viral process [GO:0016032],
endocrine pancreas development [GO:0031018],
animal organ regeneration [GO:0031100],
positive regulation of protein complex assembly [GO:0031334],
endoplasmic reticulum calcium ion homeostasis [GO:0032469],
negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471],
negative regulation of peptidyl-serine phosphorylation [GO:0033137],
cellular response to unfolded protein [GO:0034620],
cellular response to UV [GO:0034644],
limb morphogenesis [GO:0035108],
response to hydrogen peroxide [GO:0042542],
positive regulation of apoptotic process [GO:0043065],
fibroblast apoptotic process [GO:0044346],
response to ethanol [GO:0045471],
positive regulation of proteolysis [GO:0045862],
regulation of mitochondrial membrane permeability [GO:0046902],
post-embryonic camera-type eye morphogenesis [GO:0048597],
regulation of cell cycle [GO:0051726],
regulation of mitochondrial membrane potential [GO:0051881],
vagina development [GO:0060068],
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059],
thymocyte apoptotic process [GO:0070242],
cellular response to mechanical stimulus [GO:0071260],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
apoptotic signaling pathway [GO:0097190],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
activation of cysteine-type endopeptidase activity [GO:0097202],
positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103],
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901030],
apoptotic process involved in patterning of blood vessels [GO:1902262],
positive regulation of IRE1-mediated unfolded protein response [GO:1903896],
leukocyte homeostasis [GO:0001776],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
regulation of apoptotic process [GO:0042981],
homeostasis of number of cells [GO:0048872],

Molecular Function:
molecular_function [GO:0003674],
protein binding [GO:0005515],
heat shock protein binding [GO:0031072],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
ion channel binding [GO:0044325],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
protein heterodimerization activity [GO:0046982],
chaperone binding [GO:0051087],
BH domain binding [GO:0051400],

Cellular Component:
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
integral component of mitochondrial outer membrane [GO:0031307],
pore complex [GO:0046930],
Bcl-2 family protein complex [GO:0097136],
BAK complex [GO:0097145],
intracellular [GO:0005622],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
mitochondrial membrane [GO:0031966],