RFC1

replication factor C subunit 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
DNA-dependent DNA replication [GO:0006261],
transcription-coupled nucleotide-excision repair [GO:0006283],
nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296],
nucleotide-excision repair, DNA gap filling [GO:0006297],
telomere maintenance via telomerase [GO:0007004],
translesion synthesis [GO:0019985],
telomere maintenance via semi-conservative replication [GO:0032201],
nucleotide-excision repair, DNA incision [GO:0033683],
error-prone translesion synthesis [GO:0042276],
DNA damage response, detection of DNA damage [GO:0042769],
positive regulation of catalytic activity [GO:0043085],
positive regulation of transcription, DNA-templated [GO:0045893],
error-free translesion synthesis [GO:0070987],
DNA clamp unloading [GO:0090618],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
negative regulation of transcription, DNA-templated [GO:0045892],

Molecular Function:
DNA binding [GO:0003677],
DNA clamp loader activity [GO:0003689],
double-stranded DNA binding [GO:0003690],
protein binding [GO:0005515],
ATP binding [GO:0005524],
enzyme activator activity [GO:0008047],
protein domain specific binding [GO:0019904],
sequence-specific DNA binding [GO:0043565],
nucleotide binding [GO:0000166],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
DNA replication factor C complex [GO:0005663],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
Elg1 RFC-like complex [GO:0031391],
extracellular exosome [GO:0070062],
macromolecular complex [GO:0032991],