REV3L

REV3 like, DNA directed polymerase zeta catalytic subunit

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
22319213 MEF Mouse NO

GO terms:

Biological Process:
double-strand break repair via homologous recombination [GO:0000724],
DNA-dependent DNA replication [GO:0006261],
error-prone translesion synthesis [GO:0042276],
nucleic acid phosphodiester bond hydrolysis [GO:0090305],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
translesion synthesis [GO:0019985],

Molecular Function:
nucleotide binding [GO:0000166],
DNA binding [GO:0003677],
DNA-directed DNA polymerase activity [GO:0003887],
protein binding [GO:0005515],
3'-5' exonuclease activity [GO:0008408],
metal ion binding [GO:0046872],
4 iron, 4 sulfur cluster binding [GO:0051539],
nucleic acid binding [GO:0003676],
transferase activity [GO:0016740],
nucleotidyltransferase activity [GO:0016779],
iron-sulfur cluster binding [GO:0051536],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
zeta DNA polymerase complex [GO:0016035],