BAG cochaperone 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
25412315 A172, MEF Human, mouse NO

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
protein folding [GO:0006457],
brain development [GO:0007420],
extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625],
negative regulation of striated muscle cell apoptotic process [GO:0010664],
spinal cord development [GO:0021510],
cellular response to heat [GO:0034605],
cellular response to unfolded protein [GO:0034620],
positive regulation of protein import into nucleus [GO:0042307],
negative regulation of apoptotic process [GO:0043066],
muscle cell cellular homeostasis [GO:0046716],
positive regulation of protein export from nucleus [GO:0046827],
regulation of catalytic activity [GO:0050790],
protein stabilization [GO:0050821],
chaperone-mediated autophagy [GO:0061684],
aggresome assembly [GO:0070842],
cellular response to mechanical stimulus [GO:0071260],
chaperone-mediated protein transport [GO:0072321],
extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192],
negative regulation of transcription from RNA polymerase II promoter in response to stress [GO:0097201],
protein transport along microtubule [GO:0098840],
regulation of cellular response to heat [GO:1900034],
negative regulation of protein targeting to mitochondrion [GO:1903215],
positive regulation of aggrephagy [GO:1905337],
apoptotic process [GO:0006915],

Molecular Function:
adenyl-nucleotide exchange factor activity [GO:0000774],
protein binding [GO:0005515],
macromolecular complex binding [GO:0044877],
cadherin binding [GO:0045296],
dynein intermediate chain binding [GO:0045505],
chaperone binding [GO:0051087],

Cellular Component:
stress fiber [GO:0001725],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
aggresome [GO:0016235],
Z disc [GO:0030018],
neuron projection [GO:0043005],