Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
cell morphogenesis involved in differentiation [GO:0000904],
neuron migration [GO:0001764],
proteolysis [GO:0006508],
cell adhesion [GO:0007155],
axon guidance [GO:0007411],
central nervous system development [GO:0007417],
brain development [GO:0007420],
long-term memory [GO:0007616],
locomotory behavior [GO:0007626],
associative learning [GO:0008306],
glial cell differentiation [GO:0010001],
positive regulation of neuron projection development [GO:0010976],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
dendrite development [GO:0016358],
peptidyl-tyrosine phosphorylation [GO:0018108],
spinal cord patterning [GO:0021511],
ventral spinal cord development [GO:0021517],
hippocampus development [GO:0021766],
cerebral cortex tangential migration [GO:0021800],
layer formation in cerebral cortex [GO:0021819],
positive regulation of TOR signaling [GO:0032008],
positive regulation of CREB transcription factor activity [GO:0032793],
reelin-mediated signaling pathway [GO:0038026],
positive regulation of protein kinase activity [GO:0045860],
response to pain [GO:0048265],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
regulation of behavior [GO:0050795],
modulation of synaptic transmission [GO:0050804],
positive regulation of small GTPase mediated signal transduction [GO:0051057],
positive regulation of synaptic transmission, glutamatergic [GO:0051968],
long-term synaptic potentiation [GO:0060291],
positive regulation of dendritic spine morphogenesis [GO:0061003],
positive regulation of protein tyrosine kinase activity [GO:0061098],
positive regulation of synapse maturation [GO:0090129],
NMDA glutamate receptor clustering [GO:0097114],
postsynaptic density protein 95 clustering [GO:0097119],
receptor localization to synapse [GO:0097120],
lateral motor column neuron migration [GO:0097477],
positive regulation of long-term synaptic potentiation [GO:1900273],
positive regulation of lateral motor column neuron migration [GO:1902078],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
positive regulation of excitatory postsynaptic potential [GO:2000463],
positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [GO:2000969],
multicellular organism development [GO:0007275],
learning [GO:0007612],
regulation of gene expression [GO:0010468],
cell migration [GO:0016477],
dentate gyrus development [GO:0021542],
cerebral cortex development [GO:0021987],
forebrain development [GO:0030900],
protein localization to synapse [GO:0035418],
thyroid hormone metabolic process [GO:0042403],
postsynaptic density assembly [GO:0097107],

Molecular Function:
serine-type peptidase activity [GO:0008236],
metal ion binding [GO:0046872],
lipoprotein particle receptor binding [GO:0070325],
very-low-density lipoprotein particle receptor binding [GO:0070326],
extracellular matrix structural constituent [GO:0005201],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
extracellular region [GO:0005576],
extracellular space [GO:0005615],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
dendrite [GO:0030425],
extracellular matrix [GO:0031012],
neuron projection [GO:0043005],
axon [GO:0030424],
neuronal cell body [GO:0043025],
perikaryon [GO:0043204],