Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
30987592 MCF7 Breast Human YES
32148389 HDF Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
regulation of cell shape [GO:0008360],
regulation of cell size [GO:0008361],
positive regulation of gene expression [GO:0010628],
protein kinase A signaling [GO:0010737],
microvillus assembly [GO:0030033],
positive regulation of cell migration [GO:0030335],
regulation of actin filament bundle assembly [GO:0032231],
regulation of Rap protein signal transduction [GO:0032487],
negative regulation of homotypic cell-cell adhesion [GO:0034111],
negative regulation of GTPase activity [GO:0034260],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
regulation of GTPase activity [GO:0043087],
apical protein localization [GO:0045176],
establishment of protein localization [GO:0045184],
negative regulation of cell size [GO:0045792],
barbed-end actin filament capping [GO:0051016],
establishment of endothelial barrier [GO:0061028],
protein localization to plasma membrane [GO:0072659],
cellular response to thyroid hormone stimulus [GO:0097067],
regulation of ruffle assembly [GO:1900027],
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087],
regulation of organelle assembly [GO:1902115],
positive regulation of protein localization to early endosome [GO:1902966],
positive regulation of cellular protein catabolic process [GO:1903364],
negative regulation of adherens junction organization [GO:1903392],
positive regulation of early endosome to late endosome transport [GO:2000643],
actin filament capping [GO:0051693],

Molecular Function:
RNA binding [GO:0003723],
actin binding [GO:0003779],
protein binding [GO:0005515],
protein domain specific binding [GO:0019904],
cadherin binding [GO:0045296],
protein kinase A binding [GO:0051018],
ATPase binding [GO:0051117],
cytoskeletal protein binding [GO:0008092],

Cellular Component:
ruffle [GO:0001726],
extracellular space [GO:0005615],
plasma membrane [GO:0005886],
microvillus [GO:0005902],
focal adhesion [GO:0005925],
apical plasma membrane [GO:0016324],
lamellipodium [GO:0030027],
filopodium [GO:0030175],
T-tubule [GO:0030315],
midbody [GO:0030496],
cortical actin cytoskeleton [GO:0030864],
cleavage furrow [GO:0032154],
stereocilium [GO:0032420],
cell tip [GO:0051286],
extracellular exosome [GO:0070062],
cell periphery [GO:0071944],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
adherens junction [GO:0005912],
membrane [GO:0016020],
cell projection [GO:0042995],
myelin sheath [GO:0043209],
apical part of cell [GO:0045177],