BACH2
BTB domain and CNC homolog 2
Link to human orthologLink to mouse ortholog
Search for interactions with genes linked to senescence.
Status in senescence: Up-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29548335 | Saos-2 | Human | YES | |
| 30967634 | HUVEC | Human | YES | |
| 30988157 | IMR-90 | Human | YES | |
Status in senescence: Down-regulated | ||||
| Pubmed ID | Cell line | Tissue | Source | High-throughput |
| 29321003 | Primary bronchial epithelial cells derived from lung | Human | YES | |
| 31945054 | IMR-90 | Human | YES | |
GO terms:
Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
regulation of transcription, DNA-templated [GO:0006355],
regulation of transcription from RNA polymerase II promoter [GO:0006357],
nuclear import [GO:0051170],
Molecular Function:
RNA polymerase II core promoter proximal region sequence-specific DNA binding [GO:0000978],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
DNA binding [GO:0003677],
transcription factor activity, sequence-specific DNA binding [GO:0003700],
protein binding [GO:0005515],
RNA polymerase II transcription factor activity, sequence-specific DNA binding [GO:0000981],
Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
nuclear chromatin [GO:0000790],