beta-secretase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
membrane protein ectodomain proteolysis [GO:0006509],
peptide hormone processing [GO:0016486],
glucose homeostasis [GO:0042593],
negative regulation of amyloid precursor protein biosynthetic process [GO:0042985],
astrocyte activation [GO:0048143],
beta-amyloid metabolic process [GO:0050435],

Molecular Function:
aspartic-type endopeptidase activity [GO:0004190],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
endosome [GO:0005768],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
plasma membrane [GO:0005886],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
dense core granule [GO:0031045],
cytoplasm [GO:0005737],