beta-secretase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
proteolysis [GO:0006508],
membrane protein ectodomain proteolysis [GO:0006509],
response to radiation [GO:0009314],
response to lead ion [GO:0010288],
amyloid precursor protein catabolic process [GO:0042987],
positive regulation of neuron apoptotic process [GO:0043525],
cellular protein metabolic process [GO:0044267],
beta-amyloid metabolic process [GO:0050435],
detection of mechanical stimulus involved in sensory perception of pain [GO:0050966],
prepulse inhibition [GO:0060134],
cellular response to copper ion [GO:0071280],
cellular response to manganese ion [GO:0071287],
cellular response to beta-amyloid [GO:1904646],
regulation of synaptic vesicle exocytosis [GO:2000300],
memory [GO:0007613],
regulation of synaptic plasticity [GO:0048167],
modulation of synaptic transmission [GO:0050804],

Molecular Function:
beta-amyloid binding [GO:0001540],
endopeptidase activity [GO:0004175],
aspartic-type endopeptidase activity [GO:0004190],
protein binding [GO:0005515],
peptidase activity [GO:0008233],
beta-aspartyl-peptidase activity [GO:0008798],
enzyme binding [GO:0019899],
hydrolase activity [GO:0016787],

Cellular Component:
lysosome [GO:0005764],
endosome [GO:0005768],
early endosome [GO:0005769],
late endosome [GO:0005770],
multivesicular body [GO:0005771],
endoplasmic reticulum lumen [GO:0005788],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
synaptic vesicle [GO:0008021],
cell surface [GO:0009986],
endosome membrane [GO:0010008],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
axon [GO:0030424],
dendrite [GO:0030425],
cytoplasmic vesicle membrane [GO:0030659],
neuronal cell body [GO:0043025],
membrane raft [GO:0045121],
recycling endosome [GO:0055037],
Golgi-associated vesicle lumen [GO:0070931],
endoplasmic reticulum [GO:0005783],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],
presynapse [GO:0098793],