BRISC and BRCA1 A complex member 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27001068 Primary fibroblasts Mouse NO

GO terms:

Biological Process:
double-strand break repair [GO:0006302],
double-strand break repair via nonhomologous end joining [GO:0006303],
chromatin organization [GO:0006325],
apoptotic process [GO:0006915],
cellular response to DNA damage stimulus [GO:0006974],
cell cycle [GO:0007049],
signal transduction [GO:0007165],
response to ionizing radiation [GO:0010212],
protein deubiquitination [GO:0016579],
negative regulation of apoptotic process [GO:0043066],
positive regulation of DNA repair [GO:0045739],
cell division [GO:0051301],
protein K63-linked deubiquitination [GO:0070536],
signal transduction involved in G2 DNA damage checkpoint [GO:0072425],
DNA repair [GO:0006281],

Molecular Function:
peroxisome targeting sequence binding [GO:0000268],
tumor necrosis factor receptor binding [GO:0005164],
protein binding [GO:0005515],
polyubiquitin binding [GO:0031593],

Cellular Component:
nuclear ubiquitin ligase complex [GO:0000152],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
BRCA1-A complex [GO:0070531],
BRISC complex [GO:0070552],