RAPGEF3

Rap guanine nucleotide exchange factor 3

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
signal transduction [GO:0007165],
cAMP-mediated signaling [GO:0019933],
Rap protein signal transduction [GO:0032486],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
negative regulation of syncytium formation by plasma membrane fusion [GO:0034242],
positive regulation of GTPase activity [GO:0043547],
positive regulation of angiogenesis [GO:0045766],
positive regulation of protein export from nucleus [GO:0046827],
regulation of insulin secretion [GO:0050796],
positive regulation of stress fiber assembly [GO:0051496],
positive regulation of syncytium formation by plasma membrane fusion [GO:0060143],
establishment of endothelial barrier [GO:0061028],
cellular response to cAMP [GO:0071320],
positive regulation of protein acetylation [GO:1901985],
regulation of actin cytoskeleton reorganization [GO:2000249],
regulation of histone H3-K9 acetylation [GO:2000615],
positive regulation of protein phosphorylation [GO:0001934],
small GTPase mediated signal transduction [GO:0007264],
negative regulation of cardiac muscle cell apoptotic process [GO:0010667],
positive regulation of smooth muscle cell migration [GO:0014911],
negative regulation of collagen biosynthetic process [GO:0032966],
intracellular signal transduction [GO:0035556],
positive regulation of cell size [GO:0045793],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of GTP binding [GO:1904426],
positive regulation of calcium ion transmembrane transport [GO:1904427],
positive regulation of hydrogen:potassium-exchanging ATPase activity [GO:1904453],
positive regulation of actin cytoskeleton reorganization [GO:2000251],

Molecular Function:
guanyl-nucleotide exchange factor activity [GO:0005085],
protein binding [GO:0005515],
Rap guanyl-nucleotide exchange factor activity [GO:0017034],
protein domain specific binding [GO:0019904],
cAMP binding [GO:0030552],
nucleotide binding [GO:0000166],
ion channel binding [GO:0044325],

Cellular Component:
plasma membrane [GO:0005886],
microvillus [GO:0005902],
endomembrane system [GO:0012505],
membrane [GO:0016020],
lamellipodium [GO:0030027],
filopodium [GO:0030175],
cortical actin cytoskeleton [GO:0030864],
extracellular exosome [GO:0070062],
intracellular [GO:0005622],
cytoplasm [GO:0005737],
basal plasma membrane [GO:0009925],
growth cone [GO:0030426],
organelle membrane [GO:0031090],
brush border membrane [GO:0031526],
neuronal cell body [GO:0043025],
axon terminus [GO:0043679],
apical part of cell [GO:0045177],
perinuclear region of cytoplasm [GO:0048471],
cell periphery [GO:0071944],
ribbon synapse [GO:0097470],
basolateral part of cell [GO:1990794],
rod bipolar cell terminal bouton [GO:1990795],
photoreceptor cell terminal bouton [GO:1990796],