beta-1,4-galactosyltransferase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
30987592 MCF7 Breast Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
epithelial cell development [GO:0002064],
acute inflammatory response [GO:0002526],
lactose biosynthetic process [GO:0005989],
galactose metabolic process [GO:0006012],
protein N-linked glycosylation [GO:0006487],
cell adhesion [GO:0007155],
binding of sperm to zona pellucida [GO:0007339],
penetration of zona pellucida [GO:0007341],
negative regulation of cell proliferation [GO:0008285],
oligosaccharide biosynthetic process [GO:0009312],
keratan sulfate biosynthetic process [GO:0018146],
extracellular matrix organization [GO:0030198],
positive regulation of apoptotic process [GO:0043065],
neutrophil degranulation [GO:0043312],
development of secondary sexual characteristics [GO:0045136],
leukocyte migration [GO:0050900],
regulation of acrosome reaction [GO:0060046],
positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054],
angiogenesis involved in wound healing [GO:0060055],
carbohydrate metabolic process [GO:0005975],
protein glycosylation [GO:0006486],
glycoprotein biosynthetic process [GO:0009101],
mammary gland development [GO:0030879],
wound healing [GO:0042060],
regulation of cell proliferation [GO:0042127],
branching morphogenesis of an epithelial tube [GO:0048754],
regulation of cellular component movement [GO:0051270],
positive regulation of apoptotic process involved in mammary gland involution [GO:0060058],

Molecular Function:
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831],
N-acetyllactosamine synthase activity [GO:0003945],
lactose synthase activity [GO:0004461],
galactosyltransferase activity [GO:0008378],
manganese ion binding [GO:0030145],
UDP-galactosyltransferase activity [GO:0035250],
protein binding [GO:0005515],
cytoskeletal protein binding [GO:0008092],
transferase activity [GO:0016740],
transferase activity, transferring glycosyl groups [GO:0016757],
identical protein binding [GO:0042802],
alpha-tubulin binding [GO:0043014],
metal ion binding [GO:0046872],
beta-tubulin binding [GO:0048487],

Cellular Component:
Golgi trans cisterna [GO:0000138],
Golgi membrane [GO:0000139],
extracellular space [GO:0005615],
Golgi apparatus [GO:0005794],
plasma membrane [GO:0005886],
external side of plasma membrane [GO:0009897],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
basolateral plasma membrane [GO:0016323],
desmosome [GO:0030057],
filopodium [GO:0030175],
secretory granule membrane [GO:0030667],
brush border membrane [GO:0031526],
Golgi cisterna membrane [GO:0032580],
azurophil granule membrane [GO:0035577],
extracellular exosome [GO:0070062],
extracellular region [GO:0005576],
cell surface [GO:0009986],
cell projection [GO:0042995],