Raf-1 proto-oncogene, serine/threonine kinase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21881167 WI-38 Human NO
22020327 WI-38 Human NO
31744423 WI-38 Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31612616 Huh-7, Hep3B Human NO

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
activation of MAPKK activity [GO:0000186],
response to hypoxia [GO:0001666],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
signal transduction [GO:0007165],
activation of adenylate cyclase activity [GO:0007190],
heart development [GO:0007507],
negative regulation of cell proliferation [GO:0008285],
cell differentiation [GO:0030154],
platelet activation [GO:0030168],
thyroid gland development [GO:0030878],
negative regulation of protein complex assembly [GO:0031333],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
ion transmembrane transport [GO:0034220],
somatic stem cell population maintenance [GO:0035019],
regulation of Rho protein signal transduction [GO:0035023],
insulin secretion involved in cellular response to glucose stimulus [GO:0035773],
response to muscle stretch [GO:0035994],
wound healing [GO:0042060],
regulation of apoptotic process [GO:0042981],
negative regulation of apoptotic process [GO:0043066],
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154],
intermediate filament cytoskeleton organization [GO:0045104],
regulation of cell differentiation [GO:0045595],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
neurotrophin TRK receptor signaling pathway [GO:0048011],
thymus development [GO:0048538],
face development [GO:0060324],
death-inducing signaling complex assembly [GO:0071550],
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042],
regulation of cell motility [GO:2000145],
cellular glucose homeostasis [GO:0001678],
positive regulation of protein phosphorylation [GO:0001934],
phosphorylation [GO:0016310],
intracellular signal transduction [GO:0035556],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
MAP kinase kinase kinase activity [GO:0004709],
protein binding [GO:0005515],
ATP binding [GO:0005524],
adenylate cyclase binding [GO:0008179],
adenylate cyclase activator activity [GO:0010856],
enzyme binding [GO:0019899],
small GTPase binding [GO:0031267],
mitogen-activated protein kinase kinase binding [GO:0031434],
identical protein binding [GO:0042802],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
Ras GTPase binding [GO:0017016],

Cellular Component:
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
mitochondrial outer membrane [GO:0005741],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
nuclear speck [GO:0016607],
pseudopodium [GO:0031143],
nucleus [GO:0005634],
membrane [GO:0016020],