RAD9 checkpoint clamp component A

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24403312 H1299, A549, MCF7, MDA-MB 231 Human NO

GO terms:

Biological Process:
DNA replication checkpoint [GO:0000076],
DNA damage checkpoint [GO:0000077],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
intra-S DNA damage checkpoint [GO:0031573],
cellular response to ionizing radiation [GO:0071479],
nucleic acid phosphodiester bond hydrolysis [GO:0090305],
regulation of signal transduction by p53 class mediator [GO:1901796],
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231],
response to radiation [GO:0009314],

Molecular Function:
protein binding [GO:0005515],
3'-5' exonuclease activity [GO:0008408],
exodeoxyribonuclease III activity [GO:0008853],
SH3 domain binding [GO:0017124],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
histone deacetylase binding [GO:0042826],
nuclease activity [GO:0004518],
exonuclease activity [GO:0004527],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
checkpoint clamp complex [GO:0030896],