RAD50

RAD50 double strand break repair protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30920150 Primary vascular progenitor cells derived from artery Human YES

GO terms:

Biological Process:
regulation of mitotic recombination [GO:0000019],
telomere maintenance via recombination [GO:0000722],
telomere maintenance [GO:0000723],
double-strand break repair via homologous recombination [GO:0000724],
DNA double-strand break processing [GO:0000729],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
double-strand break repair [GO:0006302],
double-strand break repair via nonhomologous end joining [GO:0006303],
DNA recombination [GO:0006310],
cellular response to DNA damage stimulus [GO:0006974],
telomere maintenance via telomerase [GO:0007004],
reciprocal meiotic recombination [GO:0007131],
viral process [GO:0016032],
telomere capping [GO:0016233],
telomeric 3' overhang formation [GO:0031860],
positive regulation of protein autophosphorylation [GO:0031954],
positive regulation of telomere maintenance [GO:0032206],
DNA duplex unwinding [GO:0032508],
positive regulation of kinase activity [GO:0033674],
nucleoside monophosphate phosphorylation [GO:0046940],
chromosome organization involved in meiotic cell cycle [GO:0070192],
nucleic acid phosphodiester bond hydrolysis [GO:0090305],
regulation of signal transduction by p53 class mediator [GO:1901796],
negative regulation of telomere capping [GO:1904354],
cell cycle [GO:0007049],
regulation of mitotic cell cycle [GO:0007346],
negative regulation of viral entry into host cell [GO:0046597],
chromosome organization [GO:0051276],
meiotic cell cycle [GO:0051321],

Molecular Function:
single-stranded DNA endodeoxyribonuclease activity [GO:0000014],
DNA binding [GO:0003677],
DNA helicase activity [GO:0003678],
double-stranded telomeric DNA binding [GO:0003691],
adenylate kinase activity [GO:0004017],
protein binding [GO:0005515],
ATP binding [GO:0005524],
3'-5' exonuclease activity [GO:0008408],
protein binding, bridging [GO:0030674],
identical protein binding [GO:0042802],
single-stranded telomeric DNA binding [GO:0043047],
metal ion binding [GO:0046872],
G-quadruplex DNA binding [GO:0051880],
nucleotide binding [GO:0000166],
double-stranded DNA binding [GO:0003690],
hydrolase activity [GO:0016787],
ATPase activity [GO:0016887],
macromolecular complex binding [GO:0044877],

Cellular Component:
nuclear chromosome, telomeric region [GO:0000784],
nuclear chromatin [GO:0000790],
condensed nuclear chromosome [GO:0000794],
nucleoplasm [GO:0005654],
membrane [GO:0016020],
Mre11 complex [GO:0030870],
site of double-strand break [GO:0035861],
chromosome, telomeric region [GO:0000781],
nucleus [GO:0005634],
chromosome [GO:0005694],
inclusion body [GO:0016234],
pronucleus [GO:0045120],
perinuclear region of cytoplasm [GO:0048471],