RAD1 checkpoint DNA exonuclease

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
DNA damage checkpoint [GO:0000077],
DNA replication [GO:0006260],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],
substantia nigra development [GO:0021762],
meiotic recombination checkpoint [GO:0051598],
cellular response to ionizing radiation [GO:0071479],
nucleic acid phosphodiester bond hydrolysis [GO:0090305],
regulation of signal transduction by p53 class mediator [GO:1901796],

Molecular Function:
damaged DNA binding [GO:0003684],
protein binding [GO:0005515],
3'-5' exonuclease activity [GO:0008408],
exodeoxyribonuclease III activity [GO:0008853],
nuclease activity [GO:0004518],
exonuclease activity [GO:0004527],
hydrolase activity [GO:0016787],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
chromosome [GO:0005694],
checkpoint clamp complex [GO:0030896],
host cell nucleus [GO:0042025],
intracellular membrane-bounded organelle [GO:0043231],