Rac GTPase activating protein 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Li Fraumeni Human YES
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
mitotic cytokinesis [GO:0000281],
actomyosin contractile ring assembly [GO:0000915],
ion transport [GO:0006811],
cell cycle [GO:0007049],
signal transduction [GO:0007165],
multicellular organism development [GO:0007275],
spermatogenesis [GO:0007283],
neuroblast proliferation [GO:0007405],
sulfate transport [GO:0008272],
cell differentiation [GO:0030154],
positive regulation of cytokinesis [GO:0032467],
intracellular signal transduction [GO:0035556],
regulation of embryonic development [GO:0045995],
mitotic spindle midzone assembly [GO:0051256],
cell division [GO:0051301],
regulation of attachment of spindle microtubules to kinetochore [GO:0051988],
retrograde vesicle-mediated transport, Golgi to ER [GO:0006890],
microtubule-based movement [GO:0007018],
antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886],
positive regulation of GTPase activity [GO:0043547],
regulation of small GTPase mediated signal transduction [GO:0051056],

Molecular Function:
GTPase activator activity [GO:0005096],
phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547],
microtubule binding [GO:0008017],
lipid binding [GO:0008289],
protein kinase binding [GO:0019901],
alpha-tubulin binding [GO:0043014],
gamma-tubulin binding [GO:0043015],
metal ion binding [GO:0046872],
beta-tubulin binding [GO:0048487],
protein binding [GO:0005515],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
membrane [GO:0016020],
midbody [GO:0030496],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
cytoplasmic vesicle [GO:0031410],
cleavage furrow [GO:0032154],
spindle midzone [GO:0051233],
mitotic spindle [GO:0072686],
centralspindlin complex [GO:0097149],
acrosomal vesicle [GO:0001669],
cytosol [GO:0005829],
microtubule [GO:0005874],
extracellular exosome [GO:0070062],
Flemming body [GO:0090543],