Rac family small GTPase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
actin filament organization [GO:0007015],
signal transduction [GO:0007165],
G-protein coupled receptor signaling pathway [GO:0007186],
motor neuron axon guidance [GO:0008045],
positive regulation of cell proliferation [GO:0008284],
regulation of cell shape [GO:0008360],
regulation of hydrogen peroxide metabolic process [GO:0010310],
positive regulation of lamellipodium assembly [GO:0010592],
regulation of cell-substrate adhesion [GO:0010810],
Rac protein signal transduction [GO:0016601],
cell projection assembly [GO:0030031],
actin cytoskeleton organization [GO:0030036],
cortical cytoskeleton organization [GO:0030865],
regulation of actin cytoskeleton organization [GO:0032956],
regulation of T cell proliferation [GO:0042129],
regulation of mast cell degranulation [GO:0043304],
engulfment of apoptotic cell [GO:0043652],
bone resorption [GO:0045453],
cell redox homeostasis [GO:0045454],
regulation of protein kinase activity [GO:0045859],
regulation of small GTPase mediated signal transduction [GO:0051056],
positive regulation of protein kinase B signaling [GO:0051897],
regulation of respiratory burst [GO:0060263],
regulation of mast cell chemotaxis [GO:0060753],
lymphocyte aggregation [GO:0071593],
positive regulation of neutrophil chemotaxis [GO:0090023],
regulation of neutrophil migration [GO:1902622],
positive regulation of protein targeting to mitochondrion [GO:1903955],
chemotaxis [GO:0006935],
small GTPase mediated signal transduction [GO:0007264],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
protein kinase regulator activity [GO:0019887],
protein kinase binding [GO:0019901],
nucleotide binding [GO:0000166],

Cellular Component:
nuclear envelope [GO:0005635],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cell cortex [GO:0005938],
lamellipodium [GO:0030027],
phagocytic vesicle membrane [GO:0030670],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],
intracellular membrane-bounded organelle [GO:0043231],
extracellular exosome [GO:0070062],
intracellular [GO:0005622],
membrane [GO:0016020],