RAC1

Rac family small GTPase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
12524240 MDA-MB-231 Breast Human NO
16786104 HUVEC Human NO
17032649 MEF Mouse NO
25298426 VSMC Mouse NO
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
23519127 Liver Mouse NO
31513781 HBMEC Human NO
31806373 Primary fibroblasts derived from skin Human NO

GO terms:

Biological Process:
neuron migration [GO:0001764],
positive regulation of protein phosphorylation [GO:0001934],
mast cell chemotaxis [GO:0002551],
inflammatory response [GO:0006954],
actin filament organization [GO:0007015],
cell adhesion [GO:0007155],
cell-matrix adhesion [GO:0007160],
blood coagulation [GO:0007596],
motor neuron axon guidance [GO:0008045],
cell proliferation [GO:0008283],
regulation of cell shape [GO:0008360],
regulation of cell size [GO:0008361],
response to wounding [GO:0009611],
anatomical structure morphogenesis [GO:0009653],
regulation of hydrogen peroxide metabolic process [GO:0010310],
regulation of lamellipodium assembly [GO:0010591],
positive regulation of lamellipodium assembly [GO:0010592],
positive regulation of cell-substrate adhesion [GO:0010811],
Rac protein signal transduction [GO:0016601],
cell projection assembly [GO:0030031],
lamellipodium assembly [GO:0030032],
actin cytoskeleton organization [GO:0030036],
actin filament polymerization [GO:0030041],
regulation of cell migration [GO:0030334],
cortical cytoskeleton organization [GO:0030865],
positive regulation of microtubule polymerization [GO:0031116],
T cell costimulation [GO:0031295],
ruffle organization [GO:0031529],
negative regulation of interleukin-23 production [GO:0032707],
regulation of actin cytoskeleton organization [GO:0032956],
substrate adhesion-dependent cell spreading [GO:0034446],
positive regulation of Rho protein signal transduction [GO:0035025],
intracellular signal transduction [GO:0035556],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
Fc-epsilon receptor signaling pathway [GO:0038095],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
neutrophil degranulation [GO:0043312],
engulfment of apoptotic cell [GO:0043652],
regulation of nitric oxide biosynthetic process [GO:0045428],
bone resorption [GO:0045453],
positive regulation of DNA replication [GO:0045740],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
hepatocyte growth factor receptor signaling pathway [GO:0048012],
ephrin receptor signaling pathway [GO:0048013],
negative regulation of receptor-mediated endocytosis [GO:0048261],
cell motility [GO:0048870],
regulation of defense response to virus by virus [GO:0050690],
regulation of small GTPase mediated signal transduction [GO:0051056],
regulation of stress fiber assembly [GO:0051492],
positive regulation of stress fiber assembly [GO:0051496],
localization within membrane [GO:0051668],
positive regulation of focal adhesion assembly [GO:0051894],
positive regulation of protein kinase B signaling [GO:0051897],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
regulation of respiratory burst [GO:0060263],
cellular response to mechanical stimulus [GO:0071260],
semaphorin-plexin signaling pathway [GO:0071526],
positive regulation of neutrophil chemotaxis [GO:0090023],
ruffle assembly [GO:0097178],
positive regulation of substrate adhesion-dependent cell spreading [GO:1900026],
regulation of neutrophil migration [GO:1902622],
auditory receptor cell morphogenesis [GO:0002093],
epithelial cell morphogenesis [GO:0003382],
endocytosis [GO:0006897],
phagocytosis, engulfment [GO:0006911],
chemotaxis [GO:0006935],
hyperosmotic response [GO:0006972],
cytoskeleton organization [GO:0007010],
G-protein coupled receptor signaling pathway [GO:0007186],
small GTPase mediated signal transduction [GO:0007264],
axon guidance [GO:0007411],
regulation of fibroblast migration [GO:0010762],
regulation of neuron maturation [GO:0014041],
dendrite development [GO:0016358],
cell migration [GO:0016477],
cerebral cortex radially oriented cell migration [GO:0021799],
embryonic olfactory bulb interneuron precursor migration [GO:0021831],
cerebral cortex GABAergic interneuron development [GO:0021894],
regulation of cell morphogenesis [GO:0022604],
positive regulation of actin filament polymerization [GO:0030838],
forebrain development [GO:0030900],
non-canonical Wnt signaling pathway [GO:0035567],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
cell-cell junction organization [GO:0045216],
regulation of JAK-STAT cascade [GO:0046425],
regulation of neuronal synaptic plasticity [GO:0048168],
anatomical structure arrangement [GO:0048532],
neuron projection morphogenesis [GO:0048812],
dendrite morphogenesis [GO:0048813],
homeostasis of number of cells within a tissue [GO:0048873],
synaptic transmission, GABAergic [GO:0051932],
positive regulation of dendritic spine development [GO:0060999],
regulation of cell adhesion involved in heart morphogenesis [GO:0061344],
dopaminergic neuron differentiation [GO:0071542],
protein localization to plasma membrane [GO:0072659],
cochlea morphogenesis [GO:0090103],
midbrain dopaminergic neuron differentiation [GO:1904948],
positive regulation of ovarian follicle development [GO:2000386],

Molecular Function:
GTPase activity [GO:0003924],
protein binding [GO:0005515],
GTP binding [GO:0005525],
Rab GTPase binding [GO:0017137],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
thioesterase binding [GO:0031996],
histone deacetylase binding [GO:0042826],
macromolecular complex binding [GO:0044877],
Rho GDP-dissociation inhibitor binding [GO:0051022],
ATPase binding [GO:0051117],
nucleotide binding [GO:0000166],
hydrolase activity [GO:0016787],
GTP-dependent protein binding [GO:0030742],

Cellular Component:
Golgi membrane [GO:0000139],
cytoplasm [GO:0005737],
endoplasmic reticulum membrane [GO:0005789],
trans-Golgi network [GO:0005802],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
actin filament [GO:0005884],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cell cortex [GO:0005938],
membrane [GO:0016020],
lamellipodium [GO:0030027],
secretory granule membrane [GO:0030667],
cytoplasmic vesicle [GO:0031410],
ruffle membrane [GO:0032587],
cytoplasmic ribonucleoprotein granule [GO:0036464],
melanosome [GO:0042470],
cell projection [GO:0042995],
dendritic spine [GO:0043197],
intracellular membrane-bounded organelle [GO:0043231],
recycling endosome membrane [GO:0055038],
extracellular exosome [GO:0070062],
postsynapse [GO:0098794],
glutamatergic synapse [GO:0098978],
ficolin-1-rich granule membrane [GO:0101003],
pericentriolar material [GO:0000242],
phagocytic cup [GO:0001891],
intracellular [GO:0005622],
nucleus [GO:0005634],
extrinsic component of plasma membrane [GO:0019897],
early endosome membrane [GO:0031901],
kinocilium [GO:0060091],