PYCARD

PYD and CARD domain containing

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
myeloid dendritic cell activation [GO:0001773],
activation of innate immune response [GO:0002218],
positive regulation of defense response to virus by host [GO:0002230],
myeloid dendritic cell activation involved in immune response [GO:0002277],
positive regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002588],
positive regulation of adaptive immune response [GO:0002821],
apoptotic process [GO:0006915],
activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
regulation of autophagy [GO:0010506],
regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803],
positive regulation of actin filament polymerization [GO:0030838],
regulation of protein stability [GO:0031647],
negative regulation of NF-kappaB transcription factor activity [GO:0032088],
interleukin-1 beta production [GO:0032611],
negative regulation of interferon-beta production [GO:0032688],
positive regulation of interferon-gamma production [GO:0032729],
positive regulation of interleukin-1 beta production [GO:0032731],
positive regulation of interleukin-6 production [GO:0032755],
positive regulation of tumor necrosis factor production [GO:0032760],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
positive regulation of activated T cell proliferation [GO:0042104],
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771],
positive regulation of apoptotic process [GO:0043065],
regulation of GTPase activity [GO:0043087],
negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124],
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280],
neutrophil degranulation [GO:0043312],
macropinocytosis [GO:0044351],
innate immune response [GO:0045087],
positive regulation of JNK cascade [GO:0046330],
positive regulation of interleukin-1 beta secretion [GO:0050718],
positive regulation of phagocytosis [GO:0050766],
defense response to Gram-negative bacterium [GO:0050829],
positive regulation of T cell activation [GO:0050870],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
protein homooligomerization [GO:0051260],
defense response to virus [GO:0051607],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to lipopolysaccharide [GO:0071222],
cellular response to interleukin-1 [GO:0071347],
cellular response to tumor necrosis factor [GO:0071356],
negative regulation of protein serine/threonine kinase activity [GO:0071901],
intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332],
positive regulation of chemokine secretion [GO:0090197],
positive regulation of release of cytochrome c from mitochondria [GO:0090200],
activation of cysteine-type endopeptidase activity [GO:0097202],
negative regulation of cytokine production involved in inflammatory response [GO:1900016],
positive regulation of T cell migration [GO:2000406],
positive regulation of interleukin-8 secretion [GO:2000484],
positive regulation of interleukin-6 secretion [GO:2000778],
positive regulation of cysteine-type endopeptidase activity [GO:2001056],
positive regulation of interleukin-10 secretion [GO:2001181],
positive regulation of extrinsic apoptotic signaling pathway [GO:2001238],
regulation of intrinsic apoptotic signaling pathway [GO:2001242],
immune system process [GO:0002376],
proteolysis [GO:0006508],
response to bacterium [GO:0009617],
regulation of apoptotic process [GO:0042981],
regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043281],
regulation of inflammatory response [GO:0050727],

Molecular Function:
protease binding [GO:0002020],
interleukin-6 receptor binding [GO:0005138],
protein binding [GO:0005515],
tropomyosin binding [GO:0005523],
cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656],
myosin I binding [GO:0017024],
enzyme binding [GO:0019899],
Pyrin domain binding [GO:0032090],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
ion channel binding [GO:0044325],
protein dimerization activity [GO:0046983],
BMP receptor binding [GO:0070700],
cysteine-type endopeptidase activity involved in apoptotic process [GO:0097153],
cysteine-type endopeptidase activity [GO:0004197],
peptidase activator activity involved in apoptotic process [GO:0016505],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
IkappaB kinase complex [GO:0008385],
macromolecular complex [GO:0032991],
secretory granule lumen [GO:0034774],
azurophil granule lumen [GO:0035578],
neuronal cell body [GO:0043025],
NLRP1 inflammasome complex [GO:0072558],
NLRP3 inflammasome complex [GO:0072559],
AIM2 inflammasome complex [GO:0097169],