PXN

paxillin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
muscle contraction [GO:0006936],
cell adhesion [GO:0007155],
signal transduction [GO:0007165],
signal complex assembly [GO:0007172],
transforming growth factor beta receptor signaling pathway [GO:0007179],
substrate adhesion-dependent cell spreading [GO:0034446],
cellular response to reactive oxygen species [GO:0034614],
endothelial cell migration [GO:0043542],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
positive regulation of stress fiber assembly [GO:0051496],
growth hormone receptor signaling pathway [GO:0060396],
regulation of nucleic acid-templated transcription [GO:1903506],
activation of MAPK activity [GO:0000187],
movement of cell or subcellular component [GO:0006928],
cytoskeleton organization [GO:0007010],
integrin-mediated signaling pathway [GO:0007229],
regulation of cell shape [GO:0008360],
peptidyl-tyrosine phosphorylation [GO:0018108],
lamellipodium assembly [GO:0030032],
positive regulation of angiogenesis [GO:0045766],
positive regulation of protein kinase activity [GO:0045860],
focal adhesion assembly [GO:0048041],
branching morphogenesis of an epithelial tube [GO:0048754],
response to peptide [GO:1901652],

Molecular Function:
transcription cofactor activity [GO:0003712],
integrin binding [GO:0005178],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
vinculin binding [GO:0017166],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
ubiquitin protein ligase binding [GO:0031625],
neuropilin binding [GO:0038191],
metal ion binding [GO:0046872],
receptor signaling complex scaffold activity [GO:0030159],
macromolecular complex binding [GO:0044877],
BH4 domain binding [GO:0051435],

Cellular Component:
stress fiber [GO:0001725],
cytosol [GO:0005829],
microtubule associated complex [GO:0005875],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
focal adhesion [GO:0005925],
cell cortex [GO:0005938],
lamellipodium [GO:0030027],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
cell junction [GO:0030054],
cell leading edge [GO:0031252],