PTTG1IP

PTTG1 interacting protein

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein import into nucleus [GO:0006606],
positive regulation of protein ubiquitination [GO:0031398],
negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518],
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254],
positive regulation of cellular protein catabolic process [GO:1903364],

Molecular Function:
p53 binding [GO:0002039],
molecular_function [GO:0003674],
protein binding [GO:0005515],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
extracellular exosome [GO:0070062],
plasma membrane [GO:0005886],