PTPRS

protein tyrosine phosphatase receptor type S

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein dephosphorylation [GO:0006470],
negative regulation of neuron projection development [GO:0010977],
spinal cord development [GO:0021510],
cerebellum development [GO:0021549],
hippocampus development [GO:0021766],
cerebral cortex development [GO:0021987],
corpus callosum development [GO:0022038],
negative regulation of axon extension [GO:0030517],
negative regulation of interferon-alpha production [GO:0032687],
negative regulation of interferon-beta production [GO:0032688],
negative regulation of toll-like receptor 9 signaling pathway [GO:0034164],
peptidyl-tyrosine dephosphorylation [GO:0035335],
negative regulation of collateral sprouting [GO:0048671],
negative regulation of axon regeneration [GO:0048681],
modulation of synaptic transmission [GO:0050804],
negative regulation of dendritic spine development [GO:0061000],
establishment of endothelial intestinal barrier [GO:0090557],
synaptic membrane adhesion [GO:0099560],
cell adhesion [GO:0007155],
dephosphorylation [GO:0016311],
synapse organization [GO:0050808],

Molecular Function:
phosphoprotein phosphatase activity [GO:0004721],
protein tyrosine phosphatase activity [GO:0004725],
protein binding [GO:0005515],
heparin binding [GO:0008201],
chondroitin sulfate binding [GO:0035374],
heparan sulfate proteoglycan binding [GO:0043395],
hydrolase activity [GO:0016787],
phosphatase activity [GO:0016791],

Cellular Component:
cytosol [GO:0005829],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
integral component of synaptic vesicle membrane [GO:0030285],
axon [GO:0030424],
growth cone [GO:0030426],
perikaryon [GO:0043204],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
integral component of presynaptic membrane [GO:0099056],
integral component of postsynaptic density membrane [GO:0099061],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
cell junction [GO:0030054],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],
neuron projection [GO:0043005],
synapse [GO:0045202],