PTPRF

protein tyrosine phosphatase receptor type F

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31155234 heart heart Human NO

GO terms:

Biological Process:
protein dephosphorylation [GO:0006470],
cell adhesion [GO:0007155],
transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185],
cell migration [GO:0016477],
neuron projection regeneration [GO:0031102],
peptidyl-tyrosine dephosphorylation [GO:0035335],
regulation of axon regeneration [GO:0048679],
synaptic membrane adhesion [GO:0099560],
negative regulation of receptor binding [GO:1900121],
negative regulation of cytokine-mediated signaling pathway [GO:0001960],
homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156],
nervous system development [GO:0007399],
negative regulation of cell proliferation [GO:0008285],
regulation of neuron projection development [GO:0010975],
dephosphorylation [GO:0016311],
negative regulation of cell projection organization [GO:0031345],
negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059],
positive regulation of apoptotic process [GO:0043065],
positive regulation of neuron apoptotic process [GO:0043525],
negative regulation of insulin receptor signaling pathway [GO:0046627],
positive regulation of dendrite morphogenesis [GO:0050775],
regulation of synapse structure or activity [GO:0050803],
negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387],

Molecular Function:
protein tyrosine phosphatase activity [GO:0004725],
transmembrane receptor protein tyrosine phosphatase activity [GO:0005001],
heparin binding [GO:0008201],
chondroitin sulfate proteoglycan binding [GO:0035373],
macromolecular complex binding [GO:0044877],
cell adhesion molecule binding [GO:0050839],
phosphoprotein phosphatase activity [GO:0004721],
insulin receptor binding [GO:0005158],
hydrolase activity [GO:0016787],
phosphatase activity [GO:0016791],
receptor tyrosine kinase binding [GO:0030971],
phosphate ion binding [GO:0042301],

Cellular Component:
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
extracellular exosome [GO:0070062],
endosome [GO:0005768],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
growth cone [GO:0030426],
intracellular membrane-bounded organelle [GO:0043231],
excitatory synapse [GO:0060076],
integral component of postsynaptic density membrane [GO:0099061],