PTPN22

protein tyrosine phosphatase non-receptor type 22

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
positive regulation of defense response to virus by host [GO:0002230],
immune system process [GO:0002376],
regulation of antigen processing and presentation [GO:0002577],
regulation of leukocyte migration [GO:0002685],
protein dephosphorylation [GO:0006470],
autophagy [GO:0006914],
negative regulation of autophagy [GO:0010507],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
dephosphorylation [GO:0016311],
T cell differentiation [GO:0030217],
lipopolysaccharide-mediated signaling pathway [GO:0031663],
positive regulation of type I interferon production [GO:0032481],
response to lipopolysaccharide [GO:0032496],
negative regulation of tumor necrosis factor production [GO:0032720],
regulation of natural killer cell proliferation [GO:0032817],
positive regulation of toll-like receptor 3 signaling pathway [GO:0034141],
positive regulation of toll-like receptor 4 signaling pathway [GO:0034145],
positive regulation of toll-like receptor 7 signaling pathway [GO:0034157],
positive regulation of toll-like receptor 9 signaling pathway [GO:0034165],
peptidyl-tyrosine dephosphorylation [GO:0035335],
positive regulation of interferon-beta secretion [GO:0035549],
phosphoanandamide dephosphorylation [GO:0035644],
positive regulation of protein import into nucleus [GO:0042307],
negative regulation of JUN kinase activity [GO:0043508],
regulation of peptidyl-tyrosine phosphorylation [GO:0050730],
T cell receptor signaling pathway [GO:0050852],
regulation of T cell receptor signaling pathway [GO:0050856],
negative regulation of T cell receptor signaling pathway [GO:0050860],
negative regulation of T cell activation [GO:0050868],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070433],
cellular response to muramyl dipeptide [GO:0071225],
positive regulation of granzyme B production [GO:0071663],
negative regulation of interleukin-6 secretion [GO:1900165],
regulation of NIK/NF-kappaB signaling [GO:1901222],
positive regulation of protein K63-linked ubiquitination [GO:1902523],
positive regulation of interferon-gamma secretion [GO:1902715],
positive regulation of interferon-alpha secretion [GO:1902741],
regulation of calcium ion transmembrane transport [GO:1903169],
negative regulation of p38MAPK cascade [GO:1903753],
negative regulation of interleukin-8 secretion [GO:2000483],
positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566],
regulation of innate immune response [GO:0045088],
regulation of B cell receptor signaling pathway [GO:0050855],

Molecular Function:
phosphoprotein phosphatase activity [GO:0004721],
protein tyrosine phosphatase activity [GO:0004725],
non-membrane spanning protein tyrosine phosphatase activity [GO:0004726],
protein binding [GO:0005515],
hydrolase activity [GO:0016787],
phosphatase activity [GO:0016791],
SH3 domain binding [GO:0017124],
kinase binding [GO:0019900],
ubiquitin protein ligase binding [GO:0031625],
protein tyrosine kinase binding [GO:1990782],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytoplasmic side of plasma membrane [GO:0009898],
perinuclear region of cytoplasm [GO:0048471],
cytosol [GO:0005829],