PTPN1

protein tyrosine phosphatase non-receptor type 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
protein dephosphorylation [GO:0006470],
activation of JUN kinase activity [GO:0007257],
insulin receptor signaling pathway [GO:0008286],
regulation of signal transduction [GO:0009966],
negative regulation of signal transduction [GO:0009968],
regulation of endocytosis [GO:0030100],
negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948],
endoplasmic reticulum unfolded protein response [GO:0030968],
actin cytoskeleton reorganization [GO:0031532],
regulation of intracellular protein transport [GO:0033157],
cellular response to unfolded protein [GO:0034620],
peptidyl-tyrosine dephosphorylation [GO:0035335],
platelet-derived growth factor receptor-beta signaling pathway [GO:0035791],
IRE1-mediated unfolded protein response [GO:0036498],
negative regulation of MAP kinase activity [GO:0043407],
negative regulation of insulin receptor signaling pathway [GO:0046627],
regulation of type I interferon-mediated signaling pathway [GO:0060338],
JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397],
positive regulation of protein tyrosine kinase activity [GO:0061098],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202],
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236],
positive regulation of IRE1-mediated unfolded protein response [GO:1903896],
negative regulation of PERK-mediated unfolded protein response [GO:1903898],
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264],
positive regulation of receptor catabolic process [GO:2000646],
dephosphorylation [GO:0016311],
response to endoplasmic reticulum stress [GO:0034976],
regulation of insulin receptor signaling pathway [GO:0046626],

Molecular Function:
RNA binding [GO:0003723],
protein tyrosine phosphatase activity [GO:0004725],
insulin receptor binding [GO:0005158],
protein binding [GO:0005515],
zinc ion binding [GO:0008270],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
receptor tyrosine kinase binding [GO:0030971],
cadherin binding [GO:0045296],
ephrin receptor binding [GO:0046875],
protein phosphatase 2A binding [GO:0051721],
phosphoprotein phosphatase activity [GO:0004721],
hydrolase activity [GO:0016787],
phosphatase activity [GO:0016791],

Cellular Component:
mitochondrial matrix [GO:0005759],
early endosome [GO:0005769],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
mitochondrial crista [GO:0030061],
macromolecular complex [GO:0032991],
sorting endosome [GO:0097443],
cytoplasmic side of endoplasmic reticulum membrane [GO:0098554],
cytoplasm [GO:0005737],
membrane [GO:0016020],
cytoplasmic vesicle [GO:0031410],