PTN

pleiotrophin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31155234 heart heart Human NO
31915373 Hheart_LV_VS healthy Cardiomyocyte Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29548335 Li Fraumeni Human YES
30988157 IMR-90 Human YES
31945125 Primary astrocytes derived from brain Human YES
32972203 heartDPI7 vs healthy Endothelial cell,Brush cell (Tuft cell),Ciliated cell Mouse NO
32972203 heartDPI14 vs healthy Endothelial cell Mouse NO

GO terms:

Biological Process:
liver development [GO:0001889],
leukocyte chemotaxis involved in inflammatory response [GO:0002232],
positive regulation of leukocyte chemotaxis [GO:0002690],
transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185],
integrin-mediated signaling pathway [GO:0007229],
nervous system development [GO:0007399],
negative regulation of neuroblast proliferation [GO:0007406],
heart development [GO:0007507],
learning [GO:0007612],
memory [GO:0007613],
positive regulation of cell proliferation [GO:0008284],
regulation of cell shape [GO:0008360],
regulation of endothelial cell migration [GO:0010594],
positive regulation of cell-substrate adhesion [GO:0010811],
positive regulation of neuron projection development [GO:0010976],
response to auditory stimulus [GO:0010996],
response to activity [GO:0014823],
negative regulation of angiogenesis [GO:0016525],
spinal cord development [GO:0021510],
cerebellum development [GO:0021549],
thalamus development [GO:0021794],
bone mineralization [GO:0030282],
lung development [GO:0030324],
negative regulation of cell migration [GO:0030336],
positive regulation of bone mineralization [GO:0030501],
dendrite regeneration [GO:0031104],
regulation of myelination [GO:0031641],
response to estradiol [GO:0032355],
negative regulation of phosphoprotein phosphatase activity [GO:0032515],
response to progesterone [GO:0032570],
cellular response to UV [GO:0034644],
cellular response to platelet-derived growth factor stimulus [GO:0036120],
tissue regeneration [GO:0042246],
positive regulation of apoptotic process [GO:0043065],
receptor clustering [GO:0043113],
ossification involved in bone remodeling [GO:0043932],
estrous cycle [GO:0044849],
endothelial cell differentiation [GO:0045446],
positive regulation of ossification [GO:0045778],
negative regulation of membrane potential [GO:0045837],
decidualization [GO:0046697],
regulation of synaptic plasticity [GO:0048167],
oogenesis [GO:0048477],
positive regulation of axon regeneration [GO:0048680],
positive regulation of oligodendrocyte differentiation [GO:0048714],
negative regulation of epithelial cell proliferation [GO:0050680],
positive regulation of cell division [GO:0051781],
retinal rod cell differentiation [GO:0060221],
negative regulation of glial cell proliferation [GO:0060253],
long-term synaptic potentiation [GO:0060291],
cellular response to vitamin D [GO:0071305],
cellular response to hypoxia [GO:0071456],
negative regulation of mesenchymal cell proliferation [GO:0072201],
positive regulation of dendrite development [GO:1900006],
negative regulation of long-term synaptic potentiation [GO:1900272],
regulation of hemopoiesis [GO:1903706],
response to kainic acid [GO:1904373],
rod bipolar cell differentiation [GO:1904389],
response to ciliary neurotrophic factor [GO:1904391],
positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395],
negative regulation of neuromuscular junction development [GO:1904397],
response to nerve growth factor [GO:1990089],
regulation of stem cell population maintenance [GO:2000036],
positive regulation of hepatocyte proliferation [GO:2000347],
positive regulation of stem cell differentiation [GO:2000738],
ossification [GO:0001503],
positive regulation of cell differentiation [GO:0045597],

Molecular Function:
protein phosphatase inhibitor activity [GO:0004864],
integrin binding [GO:0005178],
protein binding [GO:0005515],
growth factor activity [GO:0008083],
heparin binding [GO:0008201],
protein kinase binding [GO:0019901],
chondroitin sulfate proteoglycan binding [GO:0035373],
chondroitin sulfate binding [GO:0035374],
vascular endothelial growth factor binding [GO:0038085],
syndecan binding [GO:0045545],
heparan sulfate binding [GO:1904399],
glycosaminoglycan binding [GO:0005539],
proteoglycan binding [GO:0043394],

Cellular Component:
extracellular region [GO:0005576],
basement membrane [GO:0005604],
extracellular space [GO:0005615],
endoplasmic reticulum [GO:0005783],
plasma membrane [GO:0005886],
cell surface [GO:0009986],
neuromuscular junction [GO:0031594],
macromolecular complex [GO:0032991],
perinuclear region of cytoplasm [GO:0048471],
presynapse [GO:0098793],
postsynapse [GO:0098794],
cytoplasm [GO:0005737],
membrane [GO:0016020],
extracellular matrix [GO:0031012],