PTK2B

protein tyrosine kinase 2 beta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
angiogenesis [GO:0001525],
oocyte maturation [GO:0001556],
response to hypoxia [GO:0001666],
positive regulation of cell-matrix adhesion [GO:0001954],
sprouting angiogenesis [GO:0002040],
adaptive immune response [GO:0002250],
marginal zone B cell differentiation [GO:0002315],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
cellular defense response [GO:0006968],
response to osmotic stress [GO:0006970],
signal transduction [GO:0007165],
cell surface receptor signaling pathway [GO:0007166],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
signal complex assembly [GO:0007172],
epidermal growth factor receptor signaling pathway [GO:0007173],
positive regulation of cytosolic calcium ion concentration [GO:0007204],
integrin-mediated signaling pathway [GO:0007229],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
regulation of cell shape [GO:0008360],
response to mechanical stimulus [GO:0009612],
response to hormone [GO:0009725],
response to glucose [GO:0009749],
response to lithium ion [GO:0010226],
positive regulation of endothelial cell migration [GO:0010595],
negative regulation of muscle cell apoptotic process [GO:0010656],
regulation of cGMP-mediated signaling [GO:0010752],
regulation of macrophage chemotaxis [GO:0010758],
positive regulation of neuron projection development [GO:0010976],
glial cell proliferation [GO:0014009],
peptidyl-tyrosine phosphorylation [GO:0018108],
cell differentiation [GO:0030154],
regulation of cell adhesion [GO:0030155],
positive regulation of cell growth [GO:0030307],
positive regulation of cell migration [GO:0030335],
negative regulation of bone mineralization [GO:0030502],
positive regulation of actin filament polymerization [GO:0030838],
neuron projection development [GO:0031175],
regulation of inositol trisphosphate biosynthetic process [GO:0032960],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
ionotropic glutamate receptor signaling pathway [GO:0035235],
response to immobilization stress [GO:0035902],
peptidyl-tyrosine autophosphorylation [GO:0038083],
interleukin-2-mediated signaling pathway [GO:0038110],
regulation of cell proliferation [GO:0042127],
response to cocaine [GO:0042220],
response to hydrogen peroxide [GO:0042542],
activation of Janus kinase activity [GO:0042976],
negative regulation of apoptotic process [GO:0043066],
stress fiber assembly [GO:0043149],
negative regulation of potassium ion transport [GO:0043267],
positive regulation of JUN kinase activity [GO:0043507],
negative regulation of neuron apoptotic process [GO:0043524],
blood vessel endothelial cell migration [GO:0043534],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
innate immune response [GO:0045087],
positive regulation of nitric oxide biosynthetic process [GO:0045429],
bone resorption [GO:0045453],
response to ethanol [GO:0045471],
negative regulation of myeloid cell differentiation [GO:0045638],
positive regulation of translation [GO:0045727],
positive regulation of angiogenesis [GO:0045766],
positive regulation of protein kinase activity [GO:0045860],
positive regulation of JNK cascade [GO:0046330],
protein autophosphorylation [GO:0046777],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
focal adhesion assembly [GO:0048041],
regulation of synaptic plasticity [GO:0048167],
positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731],
regulation of calcium-mediated signaling [GO:0050848],
positive regulation of nitric-oxide synthase activity [GO:0051000],
regulation of release of sequestered calcium ion into cytosol [GO:0051279],
response to cAMP [GO:0051591],
response to calcium ion [GO:0051592],
positive regulation of synaptic transmission, glutamatergic [GO:0051968],
long-term synaptic potentiation [GO:0060291],
long term synaptic depression [GO:0060292],
macromolecular complex assembly [GO:0065003],
chemokine-mediated signaling pathway [GO:0070098],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to retinoic acid [GO:0071300],
cellular response to fluid shear stress [GO:0071498],
endothelin receptor signaling pathway [GO:0086100],
activation of GTPase activity [GO:0090630],
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000058],
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060],
regulation of establishment of cell polarity [GO:2000114],
regulation of actin cytoskeleton reorganization [GO:2000249],
regulation of N-methyl-D-aspartate selective glutamate receptor activity [GO:2000310],
positive regulation of excitatory postsynaptic potential [GO:2000463],
positive regulation of B cell chemotaxis [GO:2000538],
positive regulation of DNA biosynthetic process [GO:2000573],
immune system process [GO:0002376],
regulation of leukocyte chemotaxis [GO:0002688],
actin filament organization [GO:0007015],
cell adhesion [GO:0007155],
phosphorylation [GO:0016310],
negative regulation of ossification [GO:0030279],
regulation of cell migration [GO:0030334],
regulation of bone mineralization [GO:0030500],
positive regulation of cellular protein metabolic process [GO:0032270],
regulation of nitric oxide biosynthetic process [GO:0045428],
regulation of angiogenesis [GO:0045765],
positive regulation of reactive oxygen species metabolic process [GO:2000379],

Molecular Function:
calmodulin-dependent protein kinase activity [GO:0004683],
protein tyrosine kinase activity [GO:0004713],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
NMDA glutamate receptor activity [GO:0004972],
receptor binding [GO:0005102],
protein binding [GO:0005515],
ATP binding [GO:0005524],
protein C-terminus binding [GO:0008022],
ubiquitin protein ligase binding [GO:0031625],
3-phosphoinositide-dependent protein kinase binding [GO:0043423],
macromolecular complex binding [GO:0044877],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
enzyme binding [GO:0019899],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
focal adhesion [GO:0005925],
cell cortex [GO:0005938],
postsynaptic density [GO:0014069],
NMDA selective glutamate receptor complex [GO:0017146],
lamellipodium [GO:0030027],
dendrite [GO:0030425],
growth cone [GO:0030426],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
neuronal cell body [GO:0043025],
dendritic spine [GO:0043197],
cell body [GO:0044297],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
apical dendrite [GO:0097440],
glutamatergic synapse [GO:0098978],
plasma membrane [GO:0005886],
membrane [GO:0016020],
cell junction [GO:0030054],
axon [GO:0030424],
cell projection [GO:0042995],
postsynapse [GO:0098794],