protein tyrosine kinase 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16523241 HDF Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30761269 A549, H1299, H46 Human NO
31983656 MSC Human YES
32599680 HCT 116 Human No
32599680 SW480 Human No

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
microtubule cytoskeleton organization [GO:0000226],
angiogenesis [GO:0001525],
vasculogenesis [GO:0001570],
neuron migration [GO:0001764],
placenta development [GO:0001890],
regulation of protein phosphorylation [GO:0001932],
positive regulation of protein phosphorylation [GO:0001934],
heart morphogenesis [GO:0003007],
nuclear migration [GO:0007097],
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169],
signal complex assembly [GO:0007172],
epidermal growth factor receptor signaling pathway [GO:0007173],
transforming growth factor beta receptor signaling pathway [GO:0007179],
integrin-mediated signaling pathway [GO:0007229],
axon guidance [GO:0007411],
positive regulation of cell proliferation [GO:0008284],
regulation of cell shape [GO:0008360],
negative regulation of autophagy [GO:0010507],
regulation of endothelial cell migration [GO:0010594],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
regulation of epithelial cell migration [GO:0010632],
positive regulation of macrophage chemotaxis [GO:0010759],
positive regulation of fibroblast migration [GO:0010763],
positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068],
peptidyl-tyrosine phosphorylation [GO:0018108],
central nervous system neuron axonogenesis [GO:0021955],
negative regulation of cell-cell adhesion [GO:0022408],
establishment of cell polarity [GO:0030010],
cell differentiation [GO:0030154],
regulation of cell adhesion [GO:0030155],
extracellular matrix organization [GO:0030198],
positive regulation of cell migration [GO:0030335],
regulation of cell adhesion mediated by integrin [GO:0033628],
netrin-activated signaling pathway [GO:0038007],
peptidyl-tyrosine autophosphorylation [GO:0038083],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
regulation of cell proliferation [GO:0042127],
negative regulation of apoptotic process [GO:0043066],
regulation of GTPase activity [GO:0043087],
endothelial cell migration [GO:0043542],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
innate immune response [GO:0045087],
regulation of osteoblast differentiation [GO:0045667],
positive regulation of protein kinase activity [GO:0045860],
negative regulation of organ growth [GO:0046621],
protein autophosphorylation [GO:0046777],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
ephrin receptor signaling pathway [GO:0048013],
cell motility [GO:0048870],
negative regulation of axonogenesis [GO:0050771],
regulation of cytoskeleton organization [GO:0051493],
regulation of focal adhesion assembly [GO:0051893],
positive regulation of protein kinase B signaling [GO:0051897],
negative regulation of synapse assembly [GO:0051964],
growth hormone receptor signaling pathway [GO:0060396],
positive regulation of wound healing [GO:0090303],
regulation of substrate adhesion-dependent cell spreading [GO:1900024],
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060],
negative regulation of anoikis [GO:2000811],
blood vessel development [GO:0001568],
protein phosphorylation [GO:0006468],
movement of cell or subcellular component [GO:0006928],
JNK cascade [GO:0007254],
multicellular organism development [GO:0007275],
positive regulation of smooth muscle cell migration [GO:0014911],
phosphorylation [GO:0016310],
positive regulation of cell growth [GO:0030307],
negative regulation of cell migration [GO:0030336],
cellular chloride ion homeostasis [GO:0030644],
positive regulation of cell adhesion [GO:0045785],
positive regulation of smooth muscle cell proliferation [GO:0048661],
positive regulation of phagocytosis [GO:0050766],
positive regulation of synaptic transmission [GO:0050806],
positive regulation of glial cell proliferation [GO:0060252],
cellular response to transforming growth factor beta stimulus [GO:0071560],

Molecular Function:
actin binding [GO:0003779],
protein kinase activity [GO:0004672],
protein tyrosine kinase activity [GO:0004713],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
receptor binding [GO:0005102],
integrin binding [GO:0005178],
protein binding [GO:0005515],
ATP binding [GO:0005524],
JUN kinase binding [GO:0008432],
protein kinase binding [GO:0019901],
protein phosphatase binding [GO:0019903],
SH2 domain binding [GO:0042169],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
phosphatase binding [GO:0019902],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
phosphatidylinositol 3-kinase binding [GO:0043548],
macromolecular complex binding [GO:0044877],

Cellular Component:
stress fiber [GO:0001725],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
cytoskeleton [GO:0005856],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
cell cortex [GO:0005938],
apical plasma membrane [GO:0016324],
lamellipodium [GO:0030027],
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234],
ciliary basal body [GO:0036064],
dendritic spine [GO:0043197],
intracellular membrane-bounded organelle [GO:0043231],
nucleolus [GO:0005730],
intercalated disc [GO:0014704],
membrane [GO:0016020],
basolateral plasma membrane [GO:0016323],
nuclear body [GO:0016604],
cell junction [GO:0030054],
sarcolemma [GO:0042383],
postsynapse [GO:0098794],
glutamatergic synapse [GO:0098978],