B2M

beta-2-microglobulin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25412306 EJ, IMR-90, HDFs, HT-18 Human NO
28213472 A549 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES
31981461 Blood Mouse NO

GO terms:

Biological Process:
retina homeostasis [GO:0001895],
positive regulation of T cell mediated cytotoxicity [GO:0001916],
response to molecule of bacterial origin [GO:0002237],
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [GO:0002480],
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481],
positive regulation of T cell cytokine production [GO:0002726],
iron ion transport [GO:0006826],
learning or memory [GO:0007611],
negative regulation of neuron projection development [GO:0010977],
antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885],
positive regulation of protein binding [GO:0032092],
T cell differentiation in thymus [GO:0033077],
regulation of iron ion transport [GO:0034756],
protein refolding [GO:0042026],
neutrophil degranulation [GO:0043312],
cellular protein metabolic process [GO:0044267],
innate immune response [GO:0045087],
regulation of erythrocyte differentiation [GO:0045646],
response to cadmium ion [GO:0046686],
positive regulation of receptor-mediated endocytosis [GO:0048260],
negative regulation of epithelial cell proliferation [GO:0050680],
regulation of defense response to virus by virus [GO:0050690],
negative regulation of neurogenesis [GO:0050768],
regulation of immune response [GO:0050776],
protein homotetramerization [GO:0051289],
iron ion homeostasis [GO:0055072],
interferon-gamma-mediated signaling pathway [GO:0060333],
cellular response to iron ion [GO:0071281],
cellular response to iron(III) ion [GO:0071283],
cellular response to nicotine [GO:0071316],
modulation of age-related behavioral decline [GO:0090647],
negative regulation of receptor binding [GO:1900121],
positive regulation of receptor binding [GO:1900122],
positive regulation of ferrous iron binding [GO:1904434],
positive regulation of transferrin receptor binding [GO:1904437],
amyloid fibril formation [GO:1990000],
positive regulation of cellular senescence [GO:2000774],
negative regulation of forebrain neuron differentiation [GO:2000978],
immune system process [GO:0002376],
regulation of membrane depolarization [GO:0003254],
immune response [GO:0006955],
cellular defense response [GO:0006968],
multicellular organism development [GO:0007275],
antibacterial humoral response [GO:0019731],
defense response to Gram-negative bacterium [GO:0050829],
defense response to Gram-positive bacterium [GO:0050830],
cellular response to lipopolysaccharide [GO:0071222],

Molecular Function:
protein binding [GO:0005515],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
external side of plasma membrane [GO:0009897],
ER to Golgi transport vesicle membrane [GO:0012507],
membrane [GO:0016020],
phagocytic vesicle membrane [GO:0030670],
early endosome membrane [GO:0031901],
early endosome lumen [GO:0031905],
specific granule lumen [GO:0035580],
MHC class I protein complex [GO:0042612],
MHC class I peptide loading complex [GO:0042824],
recycling endosome membrane [GO:0055038],
extracellular exosome [GO:0070062],
tertiary granule lumen [GO:1904724],
HFE-transferrin receptor complex [GO:1990712],