B2M

beta-2-microglobulin

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25412306 EJ, IMR-90, HDFs, HT-18 Human NO
28213472 A549 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
31945125 Primary astrocytes derived from brain Human YES
31981461 Blood Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31915373 Hheart_LA_VS healthy Cardiomyocyte Human NO

GO terms:

Biological Process:
retina homeostasis [GO:0001895],
positive regulation of T cell mediated cytotoxicity [GO:0001916],
response to molecule of bacterial origin [GO:0002237],
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent [GO:0002480],
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent [GO:0002481],
positive regulation of T cell cytokine production [GO:0002726],
iron ion transport [GO:0006826],
learning or memory [GO:0007611],
negative regulation of neuron projection development [GO:0010977],
antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885],
positive regulation of protein binding [GO:0032092],
T cell differentiation in thymus [GO:0033077],
regulation of iron ion transport [GO:0034756],
protein refolding [GO:0042026],
neutrophil degranulation [GO:0043312],
cellular protein metabolic process [GO:0044267],
innate immune response [GO:0045087],
regulation of erythrocyte differentiation [GO:0045646],
response to cadmium ion [GO:0046686],
positive regulation of receptor-mediated endocytosis [GO:0048260],
negative regulation of epithelial cell proliferation [GO:0050680],
regulation of defense response to virus by virus [GO:0050690],
negative regulation of neurogenesis [GO:0050768],
regulation of immune response [GO:0050776],
protein homotetramerization [GO:0051289],
iron ion homeostasis [GO:0055072],
interferon-gamma-mediated signaling pathway [GO:0060333],
cellular response to iron ion [GO:0071281],
cellular response to iron(III) ion [GO:0071283],
cellular response to nicotine [GO:0071316],
modulation of age-related behavioral decline [GO:0090647],
negative regulation of receptor binding [GO:1900121],
positive regulation of receptor binding [GO:1900122],
positive regulation of ferrous iron binding [GO:1904434],
positive regulation of transferrin receptor binding [GO:1904437],
amyloid fibril formation [GO:1990000],
positive regulation of cellular senescence [GO:2000774],
negative regulation of forebrain neuron differentiation [GO:2000978],
immune system process [GO:0002376],
regulation of membrane depolarization [GO:0003254],
immune response [GO:0006955],
cellular defense response [GO:0006968],
multicellular organism development [GO:0007275],
antibacterial humoral response [GO:0019731],
defense response to Gram-negative bacterium [GO:0050829],
defense response to Gram-positive bacterium [GO:0050830],
cellular response to lipopolysaccharide [GO:0071222],

Molecular Function:
protein binding [GO:0005515],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],

Cellular Component:
Golgi membrane [GO:0000139],
extracellular region [GO:0005576],
extracellular space [GO:0005615],
endoplasmic reticulum lumen [GO:0005788],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
focal adhesion [GO:0005925],
external side of plasma membrane [GO:0009897],
ER to Golgi transport vesicle membrane [GO:0012507],
membrane [GO:0016020],
phagocytic vesicle membrane [GO:0030670],
early endosome membrane [GO:0031901],
early endosome lumen [GO:0031905],
specific granule lumen [GO:0035580],
MHC class I protein complex [GO:0042612],
MHC class I peptide loading complex [GO:0042824],
recycling endosome membrane [GO:0055038],
extracellular exosome [GO:0070062],
tertiary granule lumen [GO:1904724],
HFE-transferrin receptor complex [GO:1990712],