PTEN

phosphatase and tensin homolog

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
16079851 MEF Prostate gland Mouse NO
23314408 U87-MG Human NO
27292259 Primary cells derived from glioma Glioma Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
29876362 A549 Human NO
31512783 Prostate Human NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
18250301 Primary T cells Human NO
21072054 U87, U251, U373, LN18, LN428 Human NO
21474066 IMR-90, BJ Pancreas Human, mouse NO
21695255 Primary tumor cells derived from ovary Ovary Human, mouse NO
21909130 BJ Human NO
22072715 VSMC Mouse NO
26511486 Prostate gland Mouse NO
28557373 HDF Skin Human NO
28602615 Primary stem cells derived from skin, HN13, NIH3T3, NOK-SI Human, mouse NO
28915623 BPH1, P4E6, LNCaP and PC3 cells. LNCaP and PC3 cells Prostate gland Human NO
29548335 Li Fraumeni Human YES
29743291 Prostate gland Mouse NO
29857052 HUVEC Human NO
29930746 U87-MG Human NO
30548445 A549, Primary alveoral epithelial cells, Primary embryonic fibroblasts derived from lung, Primary pulmonary fibroblasts Lung Human, mouse NO
31527305 Primary epithelial cells derived from lung, A549 Human NO
31695151 Primary epithelial cells derived from prostate, PWR-1E Human NO
31811565 Primary neuronal cells derived from brain Brain Human, mouse, rat YES
31983656 MSC Human YES
32029712 Primary synovial fibroblast Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
negative regulation of protein phosphorylation [GO:0001933],
regulation of B cell apoptotic process [GO:0002902],
transcription initiation from RNA polymerase II promoter [GO:0006367],
protein dephosphorylation [GO:0006470],
phosphatidylinositol biosynthetic process [GO:0006661],
apoptotic process [GO:0006915],
neuron-neuron synaptic transmission [GO:0007270],
synapse assembly [GO:0007416],
central nervous system development [GO:0007417],
heart development [GO:0007507],
aging [GO:0007568],
learning or memory [GO:0007611],
memory [GO:0007613],
locomotory behavior [GO:0007626],
positive regulation of cell proliferation [GO:0008284],
negative regulation of cell proliferation [GO:0008285],
response to glucose [GO:0009749],
response to zinc ion [GO:0010043],
positive regulation of gene expression [GO:0010628],
positive regulation of cardiac muscle cell apoptotic process [GO:0010666],
negative regulation of epithelial to mesenchymal transition [GO:0010719],
regulation of neuron projection development [GO:0010975],
negative regulation of neuron projection development [GO:0010977],
phosphatidylinositol 3-kinase signaling [GO:0014065],
negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067],
response to activity [GO:0014823],
dephosphorylation [GO:0016311],
cell migration [GO:0016477],
protein deubiquitination [GO:0016579],
dentate gyrus development [GO:0021542],
central nervous system neuron axonogenesis [GO:0021955],
negative regulation of cell migration [GO:0030336],
adult behavior [GO:0030534],
negative regulation of myelination [GO:0031642],
regulation of protein stability [GO:0031647],
regulation of synaptic transmission, GABAergic [GO:0032228],
central nervous system myelin maintenance [GO:0032286],
response to estradiol [GO:0032355],
regulation of cellular component size [GO:0032535],
cellular response to insulin stimulus [GO:0032869],
regulation of myeloid cell apoptotic process [GO:0033032],
negative regulation of peptidyl-serine phosphorylation [GO:0033137],
response to ATP [GO:0033198],
multicellular organismal response to stress [GO:0033555],
social behavior [GO:0035176],
peptidyl-tyrosine dephosphorylation [GO:0035335],
maternal behavior [GO:0042711],
negative regulation of apoptotic process [GO:0043066],
protein kinase B signaling [GO:0043491],
endothelial cell migration [GO:0043542],
inositol phosphate metabolic process [GO:0043647],
cellular response to leptin stimulus [GO:0044320],
locomotor rhythm [GO:0045475],
positive regulation of neuron differentiation [GO:0045666],
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736],
negative regulation of cell size [GO:0045792],
negative regulation of organ growth [GO:0046621],
response to arsenic-containing substance [GO:0046685],
inositol phosphate dephosphorylation [GO:0046855],
phosphatidylinositol dephosphorylation [GO:0046856],
platelet-derived growth factor receptor signaling pathway [GO:0048008],
negative regulation of axon regeneration [GO:0048681],
cardiac muscle tissue development [GO:0048738],
forebrain morphogenesis [GO:0048853],
brain morphogenesis [GO:0048854],
cell motility [GO:0048870],
negative regulation of epithelial cell proliferation [GO:0050680],
negative regulation of phagocytosis [GO:0050765],
negative regulation of axonogenesis [GO:0050771],
protein stabilization [GO:0050821],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
negative regulation of keratinocyte migration [GO:0051548],
negative regulation of focal adhesion assembly [GO:0051895],
regulation of protein kinase B signaling [GO:0051896],
negative regulation of protein kinase B signaling [GO:0051898],
rhythmic synaptic transmission [GO:0060024],
negative regulation of cardiac muscle cell proliferation [GO:0060044],
canonical Wnt signaling pathway [GO:0060070],
synapse maturation [GO:0060074],
prepulse inhibition [GO:0060134],
male mating behavior [GO:0060179],
long-term synaptic potentiation [GO:0060291],
long term synaptic depression [GO:0060292],
prostate gland growth [GO:0060736],
dendritic spine morphogenesis [GO:0060997],
negative regulation of dendritic spine morphogenesis [GO:0061002],
negative regulation of ERK1 and ERK2 cascade [GO:0070373],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
cellular response to electrical stimulus [GO:0071257],
cellular response to ethanol [GO:0071361],
cellular response to hypoxia [GO:0071456],
negative regulation of ribosome biogenesis [GO:0090071],
negative regulation of cell aging [GO:0090344],
negative regulation of excitatory postsynaptic potential [GO:0090394],
presynaptic membrane assembly [GO:0097105],
postsynaptic density assembly [GO:0097107],
negative regulation of potassium ion transmembrane transporter activity [GO:1901017],
negative regulation of cell cycle G1/S phase transition [GO:1902807],
negative regulation of wound healing, spreading of epidermal cells [GO:1903690],
positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984],
positive regulation of ubiquitin protein ligase activity [GO:1904668],
negative regulation of vascular smooth muscle cell proliferation [GO:1904706],
cellular response to nerve growth factor stimulus [GO:1990090],
cellular response to insulin-like growth factor stimulus [GO:1990314],
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060],
negative regulation of G1/S transition of mitotic cell cycle [GO:2000134],
negative regulation of receptor activity [GO:2000272],
positive regulation of excitatory postsynaptic potential [GO:2000463],
negative regulation of synaptic vesicle clustering [GO:2000808],
lipid metabolic process [GO:0006629],
nervous system development [GO:0007399],
neuron projection development [GO:0031175],
cellular response to decreased oxygen levels [GO:0036294],
positive regulation of apoptotic process [GO:0043065],
regulation of axon regeneration [GO:0048679],
regulation of cell cycle [GO:0051726],
regulation of cellular localization [GO:0060341],
positive regulation of apoptotic signaling pathway [GO:2001235],

Molecular Function:
phosphatidylinositol-3-phosphatase activity [GO:0004438],
phosphoprotein phosphatase activity [GO:0004721],
protein serine/threonine phosphatase activity [GO:0004722],
protein tyrosine phosphatase activity [GO:0004725],
platelet-derived growth factor receptor binding [GO:0005161],
protein binding [GO:0005515],
protein tyrosine/serine/threonine phosphatase activity [GO:0008138],
lipid binding [GO:0008289],
anaphase-promoting complex binding [GO:0010997],
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314],
enzyme binding [GO:0019899],
PDZ domain binding [GO:0030165],
ionotropic glutamate receptor binding [GO:0035255],
identical protein binding [GO:0042802],
inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717],
phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800],
ubiquitin-specific protease binding [GO:1990381],
protein tyrosine kinase binding [GO:1990782],
hydrolase activity [GO:0016787],
protein kinase binding [GO:0019901],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cytoplasmic side of plasma membrane [GO:0009898],
apical plasma membrane [GO:0016324],
PML body [GO:0016605],
myelin sheath adaxonal region [GO:0035749],
cell projection [GO:0042995],
neuron projection [GO:0043005],
dendritic spine [GO:0043197],
Schmidt-Lanterman incisure [GO:0043220],
postsynaptic membrane [GO:0045211],
postsynaptic cytosol [GO:0099524],