PSME4

proteasome activator subunit 4

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31148378 MRC-5 Human YES
31945125 Primary astrocytes derived from brain Human YES
31983656 MSC Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
protein polyubiquitination [GO:0000209],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479],
DNA repair [GO:0006281],
regulation of cellular amino acid metabolic process [GO:0006521],
cellular response to DNA damage stimulus [GO:0006974],
multicellular organism development [GO:0007275],
proteasomal ubiquitin-independent protein catabolic process [GO:0010499],
positive regulation of peptidase activity [GO:0010952],
negative regulation of G2/M transition of mitotic cell cycle [GO:0010972],
protein deubiquitination [GO:0016579],
anaphase-promoting complex-dependent catabolic process [GO:0031145],
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
spermatogenesis, exchange of chromosomal proteins [GO:0035093],
NIK/NF-kappaB signaling [GO:0038061],
Fc-epsilon receptor signaling pathway [GO:0038095],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
regulation of mRNA stability [GO:0043488],
post-translational protein modification [GO:0043687],
T cell receptor signaling pathway [GO:0050852],
transmembrane transport [GO:0055085],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418],
interleukin-1-mediated signaling pathway [GO:0070498],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
regulation of mitotic cell cycle phase transition [GO:1901990],
regulation of hematopoietic stem cell differentiation [GO:1902036],
spermatogenesis [GO:0007283],
cell differentiation [GO:0030154],

Molecular Function:
protein binding [GO:0005515],
peptidase activator activity [GO:0016504],
lysine-acetylated histone binding [GO:0070577],
proteasome binding [GO:0070628],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
nuclear speck [GO:0016607],
spermatoproteasome complex [GO:1990111],
proteasome complex [GO:0000502],
cytoplasm [GO:0005737],