proteasome 26S subunit, non-ATPase 14

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
32029712 Primary synovial fibroblast Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
19732767 H1299 Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
MAPK cascade [GO:0000165],
protein polyubiquitination [GO:0000209],
double-strand break repair via homologous recombination [GO:0000724],
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479],
double-strand break repair via nonhomologous end joining [GO:0006303],
ubiquitin-dependent protein catabolic process [GO:0006511],
regulation of cellular amino acid metabolic process [GO:0006521],
positive regulation of endopeptidase activity [GO:0010950],
negative regulation of G2/M transition of mitotic cell cycle [GO:0010972],
protein deubiquitination [GO:0016579],
anaphase-promoting complex-dependent catabolic process [GO:0031145],
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146],
tumor necrosis factor-mediated signaling pathway [GO:0033209],
NIK/NF-kappaB signaling [GO:0038061],
Fc-epsilon receptor signaling pathway [GO:0038095],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
neutrophil degranulation [GO:0043312],
regulation of mRNA stability [GO:0043488],
post-translational protein modification [GO:0043687],
response to ethanol [GO:0045471],
T cell receptor signaling pathway [GO:0050852],
transmembrane transport [GO:0055085],
Wnt signaling pathway, planar cell polarity pathway [GO:0060071],
regulation of proteasomal protein catabolic process [GO:0061136],
regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418],
interleukin-1-mediated signaling pathway [GO:0070498],
protein K63-linked deubiquitination [GO:0070536],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
regulation of mitotic cell cycle phase transition [GO:1901990],
regulation of hematopoietic stem cell differentiation [GO:1902036],
DNA repair [GO:0006281],
cellular response to DNA damage stimulus [GO:0006974],

Molecular Function:
thiol-dependent ubiquitin-specific protease activity [GO:0004843],
protein binding [GO:0005515],
metallopeptidase activity [GO:0008237],
thiol-dependent ubiquitinyl hydrolase activity [GO:0036459],
metal ion binding [GO:0046872],
endopeptidase activator activity [GO:0061133],
Lys63-specific deubiquitinase activity [GO:0061578],
proteasome binding [GO:0070628],
endopeptidase activity [GO:0004175],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
proteasome complex [GO:0000502],
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytosol [GO:0005829],
proteasome regulatory particle, lid subcomplex [GO:0008541],
proteasome accessory complex [GO:0022624],
cytosolic proteasome complex [GO:0031597],
secretory granule lumen [GO:0034774],
ficolin-1-rich granule lumen [GO:1904813],