AXIN2

axin 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
32109549 Primary murine alveolar epithelial cell type II Mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29548335 Li Fraumeni Human YES

GO terms:

Biological Process:
somitogenesis [GO:0001756],
positive regulation of protein phosphorylation [GO:0001934],
intramembranous ossification [GO:0001957],
secondary heart field specification [GO:0003139],
chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413],
cell proliferation [GO:0008283],
negative regulation of cell proliferation [GO:0008285],
positive regulation of epithelial to mesenchymal transition [GO:0010718],
positive regulation of cell death [GO:0010942],
Wnt signaling pathway [GO:0016055],
bone mineralization [GO:0030282],
regulation of mismatch repair [GO:0032423],
cellular protein localization [GO:0034613],
odontogenesis [GO:0042476],
maintenance of DNA repeat elements [GO:0043570],
negative regulation of osteoblast differentiation [GO:0045668],
mRNA stabilization [GO:0048255],
regulation of chondrocyte development [GO:0061181],
regulation of centromeric sister chromatid cohesion [GO:0070602],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
beta-catenin-TCF complex assembly [GO:1904837],
cell death [GO:0008219],
regulation of Wnt signaling pathway [GO:0030111],
positive regulation of protein kinase activity [GO:0045860],
negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [GO:2000054],

Molecular Function:
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
enzyme binding [GO:0019899],
ubiquitin protein ligase binding [GO:0031625],
I-SMAD binding [GO:0070411],
protein kinase binding [GO:0019901],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
centrosome [GO:0005813],
cytosol [GO:0005829],
beta-catenin destruction complex [GO:0030877],
macromolecular complex [GO:0032991],