axin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
positive regulation of protein phosphorylation [GO:0001934],
apoptotic process [GO:0006915],
multicellular organism development [GO:0007275],
positive regulation of peptidyl-threonine phosphorylation [GO:0010800],
Wnt signaling pathway [GO:0016055],
regulation of Wnt signaling pathway [GO:0030111],
positive regulation of protein ubiquitination [GO:0031398],
activation of protein kinase activity [GO:0032147],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
regulation of intracellular estrogen receptor signaling pathway [GO:0033146],
cellular macromolecular complex assembly [GO:0034622],
positive regulation of protein catabolic process [GO:0045732],
positive regulation of transcription, DNA-templated [GO:0045893],
positive regulation of JNK cascade [GO:0046330],
positive regulation of ubiquitin-protein transferase activity [GO:0051443],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of canonical Wnt signaling pathway [GO:0090263],
beta-catenin destruction complex assembly [GO:1904885],
beta-catenin destruction complex disassembly [GO:1904886],
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000060],
protein polyubiquitination [GO:0000209],
in utero embryonic development [GO:0001701],
regulation of protein phosphorylation [GO:0001932],
nucleocytoplasmic transport [GO:0006913],
signal transduction [GO:0007165],
sensory perception of sound [GO:0007605],
adult walking behavior [GO:0007628],
dorsal/ventral axis specification [GO:0009950],
dorsal/ventral pattern formation [GO:0009953],
negative regulation of gene expression [GO:0010629],
hemoglobin metabolic process [GO:0020027],
protein catabolic process [GO:0030163],
negative regulation of Wnt signaling pathway [GO:0030178],
positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511],
cytoplasmic microtubule organization [GO:0031122],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
erythrocyte homeostasis [GO:0034101],
negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244],
post-anal tail morphogenesis [GO:0036342],
positive regulation of JUN kinase activity [GO:0043507],
negative regulation of fat cell differentiation [GO:0045599],
positive regulation of protein kinase activity [GO:0045860],
axial mesoderm development [GO:0048318],
axial mesoderm formation [GO:0048320],
neurological system process [GO:0050877],
negative regulation of protein metabolic process [GO:0051248],
canonical Wnt signaling pathway [GO:0060070],
embryonic skeletal joint morphogenesis [GO:0060272],
head development [GO:0060322],
regulation of canonical Wnt signaling pathway [GO:0060828],
genetic imprinting [GO:0071514],

Molecular Function:
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
enzyme binding [GO:0019899],
protein kinase binding [GO:0019901],
ubiquitin protein ligase binding [GO:0031625],
signaling adaptor activity [GO:0035591],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
SMAD binding [GO:0046332],
binding, bridging [GO:0060090],
armadillo repeat domain binding [GO:0070016],
I-SMAD binding [GO:0070411],
p53 binding [GO:0002039],
receptor binding [GO:0005102],
protein C-terminus binding [GO:0008022],
protein domain specific binding [GO:0019904],
receptor signaling complex scaffold activity [GO:0030159],
protein self-association [GO:0043621],
R-SMAD binding [GO:0070412],

Cellular Component:
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
lateral plasma membrane [GO:0016328],
beta-catenin destruction complex [GO:0030877],
cytoplasmic vesicle [GO:0031410],
perinuclear region of cytoplasm [GO:0048471],
cell periphery [GO:0071944],
Golgi apparatus [GO:0005794],
cytoplasmic microtubule [GO:0005881],
plasma membrane [GO:0005886],
cell cortex [GO:0005938],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
macromolecular complex [GO:0032991],
Wnt signalosome [GO:1990909],