PSEN1

presenilin 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
21678067 C85 Human NO
25034304 NHF, PSAF Human NO
31184599 WI-38, IMR-90, HCA-2 Human YES

GO terms:

Biological Process:
autophagosome assembly [GO:0000045],
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
activation of MAPKK activity [GO:0000186],
blood vessel development [GO:0001568],
cell fate specification [GO:0001708],
somitogenesis [GO:0001756],
neuron migration [GO:0001764],
positive regulation of receptor recycling [GO:0001921],
heart looping [GO:0001947],
positive regulation of L-glutamate transport [GO:0002038],
hematopoietic progenitor cell differentiation [GO:0002244],
astrocyte activation involved in immune response [GO:0002265],
T cell activation involved in immune response [GO:0002286],
neural retina development [GO:0003407],
protein glycosylation [GO:0006486],
membrane protein ectodomain proteolysis [GO:0006509],
calcium ion transport [GO:0006816],
mitochondrial transport [GO:0006839],
cellular response to DNA damage stimulus [GO:0006974],
response to oxidative stress [GO:0006979],
negative regulation of epidermal growth factor-activated receptor activity [GO:0007175],
Notch receptor processing [GO:0007220],
learning or memory [GO:0007611],
memory [GO:0007613],
post-embryonic development [GO:0009791],
regulation of gene expression [GO:0010468],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
regulation of neuron projection development [GO:0010975],
protein transport [GO:0015031],
choline transport [GO:0015871],
synaptic vesicle targeting [GO:0016080],
protein processing [GO:0016485],
cerebellum development [GO:0021549],
cerebral cortex cell migration [GO:0021795],
Cajal-Retzius cell differentiation [GO:0021870],
dorsal/ventral neural tube patterning [GO:0021904],
embryonic limb morphogenesis [GO:0030326],
membrane protein intracellular domain proteolysis [GO:0031293],
positive regulation of protein binding [GO:0032092],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
endoplasmic reticulum calcium ion homeostasis [GO:0032469],
beta-amyloid formation [GO:0034205],
Notch receptor processing, ligand-dependent [GO:0035333],
intracellular signal transduction [GO:0035556],
positive regulation of protein import into nucleus [GO:0042307],
regulation of phosphorylation [GO:0042325],
positive regulation of phosphorylation [GO:0042327],
positive regulation of tumor necrosis factor biosynthetic process [GO:0042535],
amyloid precursor protein metabolic process [GO:0042982],
amyloid precursor protein catabolic process [GO:0042987],
myeloid dendritic cell differentiation [GO:0043011],
positive regulation of apoptotic process [GO:0043065],
negative regulation of apoptotic process [GO:0043066],
positive regulation of catalytic activity [GO:0043085],
neutrophil degranulation [GO:0043312],
negative regulation of neuron apoptotic process [GO:0043524],
skin morphogenesis [GO:0043589],
positive regulation of glycolytic process [GO:0045821],
positive regulation of transcription, DNA-templated [GO:0045893],
ephrin receptor signaling pathway [GO:0048013],
astrocyte activation [GO:0048143],
regulation of synaptic plasticity [GO:0048167],
thymus development [GO:0048538],
neuron development [GO:0048666],
skeletal system morphogenesis [GO:0048705],
brain morphogenesis [GO:0048854],
beta-amyloid metabolic process [GO:0050435],
epithelial cell proliferation [GO:0050673],
negative regulation of axonogenesis [GO:0050771],
synapse organization [GO:0050808],
positive regulation of coagulation [GO:0050820],
T cell receptor signaling pathway [GO:0050852],
neuron apoptotic process [GO:0051402],
negative regulation of ubiquitin-protein transferase activity [GO:0051444],
smooth endoplasmic reticulum calcium ion homeostasis [GO:0051563],
regulation of synaptic transmission, glutamatergic [GO:0051966],
regulation of resting membrane potential [GO:0060075],
regulation of canonical Wnt signaling pathway [GO:0060828],
positive regulation of dendritic spine development [GO:0060999],
calcium ion transmembrane transport [GO:0070588],
modulation of age-related behavioral decline [GO:0090647],
cell-cell adhesion [GO:0098609],
cellular response to beta-amyloid [GO:1904646],
negative regulation of core promoter binding [GO:1904797],
neuron projection maintenance [GO:1990535],
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [GO:2000059],
negative regulation of apoptotic signaling pathway [GO:2001234],
negative regulation of protein phosphorylation [GO:0001933],
positive regulation of protein phosphorylation [GO:0001934],
myeloid leukocyte differentiation [GO:0002573],
negative regulation of protein kinase activity [GO:0006469],
proteolysis [GO:0006508],
cellular calcium ion homeostasis [GO:0006874],
autophagy [GO:0006914],
apoptotic process [GO:0006915],
cell adhesion [GO:0007155],
regulation of epidermal growth factor-activated receptor activity [GO:0007176],
Notch signaling pathway [GO:0007219],
brain development [GO:0007420],
heart development [GO:0007507],
embryo development [GO:0009790],
cerebral cortex development [GO:0021987],
neurogenesis [GO:0022008],
neuron differentiation [GO:0030182],
forebrain development [GO:0030900],
segmentation [GO:0035282],
locomotion [GO:0040011],
anagen [GO:0042640],
regulation of protein binding [GO:0043393],
positive regulation of MAP kinase activity [GO:0043406],
cellular protein metabolic process [GO:0044267],
positive regulation of protein kinase activity [GO:0045860],
protein maturation [GO:0051604],
long-term synaptic potentiation [GO:0060291],

Molecular Function:
endopeptidase activity [GO:0004175],
aspartic-type endopeptidase activity [GO:0004190],
calcium channel activity [GO:0005262],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
PDZ domain binding [GO:0030165],
aspartic endopeptidase activity, intramembrane cleaving [GO:0042500],
cadherin binding [GO:0045296],
ATPase binding [GO:0051117],
growth factor receptor binding [GO:0070851],
peptidase activity [GO:0008233],
hydrolase activity [GO:0016787],

Cellular Component:
Golgi membrane [GO:0000139],
kinetochore [GO:0000776],
nucleus [GO:0005634],
nuclear outer membrane [GO:0005640],
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
mitochondrial inner membrane [GO:0005743],
lysosomal membrane [GO:0005765],
endoplasmic reticulum [GO:0005783],
endoplasmic reticulum membrane [GO:0005789],
smooth endoplasmic reticulum [GO:0005790],
rough endoplasmic reticulum [GO:0005791],
Golgi apparatus [GO:0005794],
centrosome [GO:0005813],
plasma membrane [GO:0005886],
integral component of plasma membrane [GO:0005887],
cell cortex [GO:0005938],
synaptic vesicle [GO:0008021],
cell surface [GO:0009986],
membrane [GO:0016020],
integral component of membrane [GO:0016021],
aggresome [GO:0016235],
apical plasma membrane [GO:0016324],
Z disc [GO:0030018],
cell junction [GO:0030054],
axon [GO:0030424],
growth cone [GO:0030426],
neuromuscular junction [GO:0031594],
early endosome membrane [GO:0031901],
nuclear membrane [GO:0031965],
macromolecular complex [GO:0032991],
ciliary rootlet [GO:0035253],
azurophil granule membrane [GO:0035577],
sarcolemma [GO:0042383],
neuron projection [GO:0043005],
neuronal cell body [GO:0043025],
dendritic shaft [GO:0043198],
membrane raft [GO:0045121],
perinuclear region of cytoplasm [GO:0048471],
gamma-secretase complex [GO:0070765],
integral component of presynaptic membrane [GO:0099056],
intracellular [GO:0005622],
cytoplasm [GO:0005737],
endosome [GO:0005768],
early endosome [GO:0005769],
dendrite [GO:0030425],
cytoplasmic vesicle [GO:0031410],
cell projection [GO:0042995],
membrane-bounded organelle [GO:0043227],
synapse [GO:0045202],
synaptic membrane [GO:0097060],