PRPS1

phosphoribosyl pyrophosphate synthetase 1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
29321003 Primary bronchial epithelial cells derived from lung Human YES

GO terms:

Biological Process:
5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015],
purine nucleobase metabolic process [GO:0006144],
purine nucleotide biosynthetic process [GO:0006164],
pyrimidine nucleotide biosynthetic process [GO:0006221],
nervous system development [GO:0007399],
nucleoside metabolic process [GO:0009116],
ribonucleoside monophosphate biosynthetic process [GO:0009156],
nucleotide biosynthetic process [GO:0009165],
phosphorylation [GO:0016310],
urate biosynthetic process [GO:0034418],
hypoxanthine biosynthetic process [GO:0046101],
AMP biosynthetic process [GO:0006167],
ribose phosphate metabolic process [GO:0019693],
cellular biosynthetic process [GO:0044249],

Molecular Function:
magnesium ion binding [GO:0000287],
ribose phosphate diphosphokinase activity [GO:0004749],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
identical protein binding [GO:0042802],
protein homodimerization activity [GO:0042803],
nucleotide binding [GO:0000166],
AMP binding [GO:0016208],
transferase activity [GO:0016740],
GDP binding [GO:0019003],
carbohydrate binding [GO:0030246],
ADP binding [GO:0043531],
metal ion binding [GO:0046872],

Cellular Component:
ribose phosphate diphosphokinase complex [GO:0002189],
cytoplasm [GO:0005737],
cytosol [GO:0005829],
macromolecular complex [GO:0032991],