PRMT6

protein arginine methyltransferase 6

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
22904064 MEF Mouse NO
27323813 PC-3 Human NO

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
base-excision repair [GO:0006284],
regulation of mitochondrion organization [GO:0010821],
viral process [GO:0016032],
histone methylation [GO:0016571],
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [GO:0019919],
negative regulation of histone deacetylation [GO:0031064],
histone H3-R2 methylation [GO:0034970],
histone H4-R3 methylation [GO:0043985],
regulation of megakaryocyte differentiation [GO:0045652],
negative regulation of transcription, DNA-templated [GO:0045892],
negative regulation of histone H3-K4 methylation [GO:0051572],
cellular senescence [GO:0090398],
regulation of signal transduction by p53 class mediator [GO:1901796],
DNA repair [GO:0006281],
chromatin organization [GO:0006325],
protein methylation [GO:0006479],
cellular response to DNA damage stimulus [GO:0006974],
methylation [GO:0032259],
peptidyl-arginine N-methylation [GO:0035246],

Molecular Function:
chromatin binding [GO:0003682],
protein binding [GO:0005515],
histone-arginine N-methyltransferase activity [GO:0008469],
protein-arginine N-methyltransferase activity [GO:0016274],
protein-arginine omega-N monomethyltransferase activity [GO:0035241],
protein-arginine omega-N asymmetric methyltransferase activity [GO:0035242],
histone methyltransferase activity [GO:0042054],
histone binding [GO:0042393],
histone methyltransferase activity (H4-R3 specific) [GO:0044020],
histone methyltransferase activity (H3-R2 specific) [GO:0070611],
histone methyltransferase activity (H2A-R3 specific) [GO:0070612],
methyltransferase activity [GO:0008168],
transferase activity [GO:0016740],

Cellular Component:
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
nucleolus [GO:0005730],