PRKN

parkin RBR E3 ubiquitin protein ligase

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
25714760 BEAS-2B Human NO
29321003 Primary bronchial epithelial cells derived from lung Human YES
30892080 Primary epithelial cells derived from lung Mouse NO
32963699 Primary endothelial cells derived from aorta Human No
32963699 Primary endothelial cells derived from aorta Human No

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
33299530 kidney Mouse No

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
protein polyubiquitination [GO:0000209],
mitochondrial fission [GO:0000266],
mitophagy [GO:0000422],
macromitophagy [GO:0000423],
negative regulation of protein phosphorylation [GO:0001933],
startle response [GO:0001964],
ubiquitin-dependent protein catabolic process [GO:0006511],
protein monoubiquitination [GO:0006513],
response to oxidative stress [GO:0006979],
mitochondrion organization [GO:0007005],
central nervous system development [GO:0007417],
learning [GO:0007612],
adult locomotory behavior [GO:0008344],
proteasomal protein catabolic process [GO:0010498],
regulation of autophagy [GO:0010506],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
positive regulation of mitochondrial fusion [GO:0010636],
negative regulation of mitochondrial fusion [GO:0010637],
regulation of mitochondrion organization [GO:0010821],
regulation of glucose metabolic process [GO:0010906],
free ubiquitin chain polymerization [GO:0010994],
regulation of dopamine secretion [GO:0014059],
macroautophagy [GO:0016236],
protein ubiquitination [GO:0016567],
protein deubiquitination [GO:0016579],
regulation of protein ubiquitination [GO:0031396],
regulation of protein stability [GO:0031647],
protein destabilization [GO:0031648],
positive regulation of protein binding [GO:0032092],
negative regulation of actin filament bundle assembly [GO:0032232],
regulation of lipid transport [GO:0032368],
positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436],
negative regulation of glucokinase activity [GO:0033132],
cellular response to unfolded protein [GO:0034620],
response to endoplasmic reticulum stress [GO:0034976],
synaptic transmission, glutamatergic [GO:0035249],
protein K29-linked ubiquitination [GO:0035519],
ERAD pathway [GO:0036503],
regulation of dopamine metabolic process [GO:0042053],
norepinephrine metabolic process [GO:0042415],
dopamine metabolic process [GO:0042417],
regulation of apoptotic process [GO:0042981],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161],
positive regulation of DNA binding [GO:0043388],
negative regulation of neuron apoptotic process [GO:0043524],
cellular protein catabolic process [GO:0044257],
cellular protein metabolic process [GO:0044267],
protein K27-linked ubiquitination [GO:0044314],
negative regulation by host of viral genome replication [GO:0044828],
positive regulation of protein catabolic process [GO:0045732],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of JNK cascade [GO:0046329],
negative regulation of insulin secretion [GO:0046676],
protein stabilization [GO:0050821],
positive regulation of neurotransmitter uptake [GO:0051582],
dopamine uptake involved in synaptic transmission [GO:0051583],
protein autoubiquitination [GO:0051865],
regulation of mitochondrial membrane potential [GO:0051881],
zinc ion homeostasis [GO:0055069],
negative regulation of cell death [GO:0060548],
regulation of canonical Wnt signaling pathway [GO:0060828],
parkin-mediated mitophagy in response to mitochondrial depolarization [GO:0061734],
neuron cellular homeostasis [GO:0070050],
protein K63-linked ubiquitination [GO:0070534],
protein localization to mitochondrion [GO:0070585],
aggresome assembly [GO:0070842],
protein K48-linked ubiquitination [GO:0070936],
protein K11-linked ubiquitination [GO:0070979],
cellular response to manganese ion [GO:0071287],
protein K6-linked ubiquitination [GO:0085020],
negative regulation of canonical Wnt signaling pathway [GO:0090090],
positive regulation of mitochondrial fission [GO:0090141],
negative regulation of release of cytochrome c from mitochondria [GO:0090201],
cellular response to toxic substance [GO:0097237],
mitophagy in response to mitochondrial depolarization [GO:0098779],
mitochondrion to lysosome transport [GO:0099074],
regulation of cellular response to oxidative stress [GO:1900407],
negative regulation of neuron death [GO:1901215],
positive regulation of proteasomal protein catabolic process [GO:1901800],
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236],
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254],
negative regulation of primary amine oxidase activity [GO:1902283],
positive regulation of protein linear polyubiquitination [GO:1902530],
regulation of synaptic vesicle transport [GO:1902803],
negative regulation of oxidative stress-induced cell death [GO:1903202],
regulation of protein targeting to mitochondrion [GO:1903214],
positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265],
cellular response to dopamine [GO:1903351],
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903377],
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway [GO:1903382],
negative regulation of exosomal secretion [GO:1903542],
positive regulation of mitophagy [GO:1903599],
positive regulation of dendrite extension [GO:1903861],
negative regulation of spontaneous neurotransmitter secretion [GO:1904049],
positive regulation of retrograde transport, endosome to Golgi [GO:1905281],
negative regulation of intralumenal vesicle formation [GO:1905366],
positive regulation of protein localization to membrane [GO:1905477],
regulation of reactive oxygen species metabolic process [GO:2000377],
negative regulation of reactive oxygen species metabolic process [GO:2000378],
synaptic transmission, dopaminergic [GO:0001963],
autophagy [GO:0006914],
locomotory behavior [GO:0007626],
regulation of gene expression [GO:0010468],
positive regulation of mitochondrial membrane potential [GO:0010918],
protein metabolic process [GO:0019538],
positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774],
positive regulation of apoptotic process [GO:0043065],
mitochondrial fragmentation involved in apoptotic process [GO:0043653],
regulation of neurotransmitter secretion [GO:0046928],
modulation of synaptic transmission [GO:0050804],
mitochondrion localization [GO:0051646],
negative regulation of synaptic transmission, glutamatergic [GO:0051967],
negative regulation of mitochondrial fission [GO:0090258],
negative regulation of excitatory postsynaptic potential [GO:0090394],
positive regulation of macromitophagy [GO:1901526],
negative regulation of oxidative stress-induced neuron death [GO:1903204],
negative regulation of reactive oxygen species biosynthetic process [GO:1903427],
cellular response to hydrogen sulfide [GO:1904881],
cellular response to L-glutamate [GO:1905232],
positive regulation of ATP biosynthetic process [GO:2001171],

Molecular Function:
transcription regulatory region sequence-specific DNA binding [GO:0000976],
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding [GO:0001227],
G-protein coupled receptor binding [GO:0001664],
actin binding [GO:0003779],
ubiquitin-protein transferase activity [GO:0004842],
protein binding [GO:0005515],
beta-catenin binding [GO:0008013],
zinc ion binding [GO:0008270],
tubulin binding [GO:0015631],
SH3 domain binding [GO:0017124],
enzyme binding [GO:0019899],
kinase binding [GO:0019900],
protein kinase binding [GO:0019901],
PDZ domain binding [GO:0030165],
Hsp70 protein binding [GO:0030544],
heat shock protein binding [GO:0031072],
ubiquitin conjugating enzyme binding [GO:0031624],
ubiquitin protein ligase binding [GO:0031625],
identical protein binding [GO:0042802],
histone deacetylase binding [GO:0042826],
ubiquitin binding [GO:0043130],
phospholipase binding [GO:0043274],
macromolecular complex binding [GO:0044877],
chaperone binding [GO:0051087],
ubiquitin protein ligase activity [GO:0061630],
cullin family protein binding [GO:0097602],
ubiquitin-specific protease binding [GO:1990381],
F-box domain binding [GO:1990444],
transferase activity [GO:0016740],
metal ion binding [GO:0046872],

Cellular Component:
ubiquitin ligase complex [GO:0000151],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
endoplasmic reticulum [GO:0005783],
Golgi apparatus [GO:0005794],
cytosol [GO:0005829],
aggresome [GO:0016235],
nuclear speck [GO:0016607],
SCF ubiquitin ligase complex [GO:0019005],
neuron projection [GO:0043005],
perinuclear region of cytoplasm [GO:0048471],
Lewy body [GO:0097413],
presynapse [GO:0098793],
mitochondrion-derived vesicle [GO:0099073],
Parkin-FBXW7-Cul1 ubiquitin ligase complex [GO:1990452],
Golgi membrane [GO:0000139],
endoplasmic reticulum membrane [GO:0005789],
synaptic vesicle [GO:0008021],
postsynaptic density [GO:0014069],
cell junction [GO:0030054],
axon [GO:0030424],
synaptic vesicle membrane [GO:0030672],
cytoplasmic vesicle [GO:0031410],
macromolecular complex [GO:0032991],
cell projection [GO:0042995],
neuronal cell body [GO:0043025],
terminal bouton [GO:0043195],
membrane raft [GO:0045121],
synapse [GO:0045202],
intracellular vesicle [GO:0097708],