PRKD1

protein kinase D1

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
24828530 IMR-90 Human NO
29548335 Saos-2 Human YES

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
angiogenesis [GO:0001525],
positive regulation of endothelial cell proliferation [GO:0001938],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
inflammatory response [GO:0006954],
Golgi organization [GO:0007030],
signal transduction [GO:0007165],
integrin-mediated signaling pathway [GO:0007229],
Ras protein signal transduction [GO:0007265],
positive regulation of autophagy [GO:0010508],
positive regulation of endothelial cell migration [GO:0010595],
regulation of keratinocyte proliferation [GO:0010837],
positive regulation of neuron projection development [GO:0010976],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
sphingolipid biosynthetic process [GO:0030148],
regulation of protein stability [GO:0031647],
positive regulation of CREB transcription factor activity [GO:0032793],
positive regulation of peptidyl-serine phosphorylation [GO:0033138],
cellular response to amino acid starvation [GO:0034198],
cellular response to oxidative stress [GO:0034599],
intracellular signal transduction [GO:0035556],
cellular response to vascular endothelial growth factor stimulus [GO:0035924],
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033],
positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123],
positive regulation of blood vessel endothelial cell migration [GO:0043536],
positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552],
innate immune response [GO:0045087],
positive regulation of osteoblast differentiation [GO:0045669],
positive regulation of angiogenesis [GO:0045766],
negative regulation of endocytosis [GO:0045806],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
protein autophosphorylation [GO:0046777],
vascular endothelial growth factor receptor signaling pathway [GO:0048010],
Golgi vesicle transport [GO:0048193],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
negative regulation of cell death [GO:0060548],
cellular response to hydroperoxide [GO:0071447],
protein kinase D signaling [GO:0089700],
positive regulation of histone deacetylase activity [GO:1901727],
positive regulation of endothelial cell chemotaxis [GO:2001028],
regulation of integrin-mediated signaling pathway [GO:2001044],
immune system process [GO:0002376],
nervous system development [GO:0007399],
phosphorylation [GO:0016310],
cell differentiation [GO:0030154],
positive regulation of protein import into nucleus [GO:0042307],
defense response to Gram-negative bacterium [GO:0050829],
regulation of release of sequestered calcium ion into cytosol [GO:0051279],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
protein kinase C activity [GO:0004697],
calcium-dependent protein kinase C activity [GO:0004698],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase activity [GO:0016301],
identical protein binding [GO:0042802],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
transferase activity [GO:0016740],

Cellular Component:
autophagosome membrane [GO:0000421],
Golgi apparatus [GO:0005794],
trans-Golgi network [GO:0005802],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
nucleus [GO:0005634],
cytoplasm [GO:0005737],
cell-cell junction [GO:0005911],
cell cortex [GO:0005938],
membrane [GO:0016020],