PRKCZ

protein kinase C zeta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31534052 MDCK Kidney Mouse, dog NO

GO terms:

Biological Process:
microtubule cytoskeleton organization [GO:0000226],
positive regulation of cell-matrix adhesion [GO:0001954],
protein phosphorylation [GO:0006468],
inflammatory response [GO:0006954],
signal transduction [GO:0007165],
transforming growth factor beta receptor signaling pathway [GO:0007179],
long-term memory [GO:0007616],
positive regulation of cell proliferation [GO:0008284],
cell migration [GO:0016477],
peptidyl-serine phosphorylation [GO:0018105],
establishment of cell polarity [GO:0030010],
negative regulation of protein complex assembly [GO:0031333],
activation of phospholipase D activity [GO:0031584],
activation of protein kinase B activity [GO:0032148],
positive regulation of interleukin-4 production [GO:0032753],
cellular response to insulin stimulus [GO:0032869],
intracellular signal transduction [GO:0035556],
negative regulation of apoptotic process [GO:0043066],
positive regulation of T-helper 2 cell differentiation [GO:0045630],
negative regulation of insulin receptor signaling pathway [GO:0046627],
positive regulation of insulin receptor signaling pathway [GO:0046628],
vesicle transport along microtubule [GO:0047496],
negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732],
positive regulation of NF-kappaB transcription factor activity [GO:0051092],
negative regulation of hydrolase activity [GO:0051346],
membrane depolarization [GO:0051899],
membrane hyperpolarization [GO:0060081],
long-term synaptic potentiation [GO:0060291],
positive regulation of ERK1 and ERK2 cascade [GO:0070374],
protein kinase C signaling [GO:0070528],
protein localization to plasma membrane [GO:0072659],
neuron projection extension [GO:1990138],
positive regulation of excitatory postsynaptic potential [GO:2000463],
positive regulation of T-helper 2 cell cytokine production [GO:2000553],
positive regulation of interleukin-5 secretion [GO:2000664],
positive regulation of interleukin-13 secretion [GO:2000667],
positive regulation of interleukin-10 secretion [GO:2001181],
cell surface receptor signaling pathway [GO:0007166],
phosphorylation [GO:0016310],
cellular protein localization [GO:0034613],
positive regulation of synaptic transmission [GO:0050806],
positive regulation of protein transport [GO:0051222],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
calcium-dependent protein kinase C activity [GO:0004698],
protein binding [GO:0005515],
ATP binding [GO:0005524],
potassium channel regulator activity [GO:0015459],
protein kinase binding [GO:0019901],
phospholipase binding [GO:0043274],
insulin receptor substrate binding [GO:0043560],
macromolecular complex binding [GO:0044877],
metal ion binding [GO:0046872],
14-3-3 protein binding [GO:0071889],
nucleotide binding [GO:0000166],
protein kinase C activity [GO:0004697],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
stress fiber [GO:0001725],
nuclear envelope [GO:0005635],
cytoplasm [GO:0005737],
endosome [GO:0005768],
microtubule organizing center [GO:0005815],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
bicellular tight junction [GO:0005923],
postsynaptic density [GO:0014069],
membrane [GO:0016020],
apical plasma membrane [GO:0016324],
nuclear matrix [GO:0016363],
cell junction [GO:0030054],
cell leading edge [GO:0031252],
vesicle [GO:0031982],
myelin sheath abaxonal region [GO:0035748],
axon hillock [GO:0043203],
membrane raft [GO:0045121],
apical cortex [GO:0045179],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
glutamatergic synapse [GO:0098978],
nucleus [GO:0005634],
cell cortex [GO:0005938],
intracellular membrane-bounded organelle [GO:0043231],