ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
31983656 MSC Human YES

GO terms:

Biological Process:
actin filament-based process [GO:0030029],
endocytic recycling [GO:0032456],
positive regulation of GTPase activity [GO:0043547],
cellular response to nerve growth factor stimulus [GO:1990090],

Molecular Function:
GTPase activator activity [GO:0005096],
Rab GTPase binding [GO:0017137],
metal ion binding [GO:0046872],
phosphatidylinositol-3,5-bisphosphate binding [GO:0080025],
protein binding [GO:0005515],

Cellular Component:
ruffle [GO:0001726],
endosome membrane [GO:0010008],
membrane [GO:0016020],
endosome [GO:0005768],