AURKB

aurora kinase B

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
22024481 HDF, HUVEC Human NO
23180582 Hs294T, SK-Mel-2, SK-Mel-5, SK-Mel-28 cells Melanoma implants from patients Human NO
23448364 MEF Mouse NO
27323328 Saos-2,H1299, HT18, MCF7, MDA-MB-231, Li-Fraumeni Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
29548335 Saos-2 Human YES
29606879 Sk-Hep-1 Human NO
30987592 MCF7 Breast Human YES
30988157 IMR-90 Human YES
31578521 hTERT-RPE1, Hep 3B, Huh-7 Human YES
31799499 IMR-90, A549, SK-HEP-1, Huh-7, HLF Human NO
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
negative regulation of transcription from RNA polymerase II promoter [GO:0000122],
negative regulation of B cell apoptotic process [GO:0002903],
protein phosphorylation [GO:0006468],
ubiquitin-dependent protein catabolic process [GO:0006511],
spindle organization [GO:0007051],
mitotic spindle organization [GO:0007052],
mitotic spindle assembly checkpoint [GO:0007094],
aging [GO:0007568],
cell proliferation [GO:0008283],
attachment of spindle microtubules to kinetochore [GO:0008608],
abscission [GO:0009838],
histone modification [GO:0016570],
anaphase-promoting complex-dependent catabolic process [GO:0031145],
negative regulation of protein binding [GO:0032091],
positive regulation of telomere maintenance via telomerase [GO:0032212],
regulation of cytokinesis [GO:0032465],
negative regulation of cytokinesis [GO:0032466],
positive regulation of cytokinesis [GO:0032467],
protein localization to kinetochore [GO:0034501],
cellular response to UV [GO:0034644],
cleavage furrow formation [GO:0036089],
histone H3-S28 phosphorylation [GO:0043988],
mitotic cytokinesis checkpoint [GO:0044878],
protein autophosphorylation [GO:0046777],
mitotic spindle midzone assembly [GO:0051256],
positive regulation of telomerase activity [GO:0051973],
regulation of chromosome segregation [GO:0051983],
regulation of signal transduction by p53 class mediator [GO:1901796],
positive regulation of telomere capping [GO:1904355],
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore [GO:1905116],
cell cycle [GO:0007049],
phosphorylation [GO:0016310],
cell division [GO:0051301],

Molecular Function:
protein serine/threonine kinase activity [GO:0004674],
protein serine/threonine/tyrosine kinase activity [GO:0004712],
protein binding [GO:0005515],
ATP binding [GO:0005524],
kinase binding [GO:0019900],
histone serine kinase activity [GO:0035174],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
protein kinase activity [GO:0004672],
kinase activity [GO:0016301],
transferase activity [GO:0016740],

Cellular Component:
kinetochore [GO:0000776],
condensed chromosome, centromeric region [GO:0000779],
condensed nuclear chromosome, centromeric region [GO:0000780],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
spindle [GO:0005819],
cytosol [GO:0005829],
spindle microtubule [GO:0005876],
chromocenter [GO:0010369],
midbody [GO:0030496],
spindle pole centrosome [GO:0031616],
chromosome passenger complex [GO:0032133],
spindle midzone [GO:0051233],
mitotic spindle midzone [GO:1990023],
chromosome, centromeric region [GO:0000775],
chromosome [GO:0005694],
cytoplasm [GO:0005737],
cytoskeleton [GO:0005856],
mitotic spindle pole [GO:0097431],