PRKCD

protein kinase C delta

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
15282327 HDF Skin Human NO
19279193 HEK 293, TIG-1 Human NO
24917460 Mv 1 Lu Mink NO
28844647 BJ, WI-38, IMR-90, MRC-5, HFF-1, HCA2 Skin, Lung Human YES
29321003 Primary bronchial epithelial cells derived from lung Human YES
31155496 Primary β cells derived from pancreas Mouse YES
31945125 Primary astrocytes derived from brain Human YES

GO terms:

Biological Process:
stimulatory C-type lectin receptor signaling pathway [GO:0002223],
protein phosphorylation [GO:0006468],
apoptotic process [GO:0006915],
cell cycle [GO:0007049],
signal transduction [GO:0007165],
intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631],
regulation of receptor activity [GO:0010469],
immunoglobulin mediated immune response [GO:0016064],
histone phosphorylation [GO:0016572],
peptidyl-serine phosphorylation [GO:0018105],
peptidyl-threonine phosphorylation [GO:0018107],
peptidyl-tyrosine phosphorylation [GO:0018108],
termination of signal transduction [GO:0023021],
platelet activation [GO:0030168],
negative regulation of actin filament polymerization [GO:0030837],
positive regulation of endodeoxyribonuclease activity [GO:0032079],
negative regulation of protein binding [GO:0032091],
activation of protein kinase activity [GO:0032147],
interleukin-10 production [GO:0032613],
interleukin-12 production [GO:0032615],
positive regulation of superoxide anion generation [GO:0032930],
regulation of actin cytoskeleton organization [GO:0032956],
negative regulation of glial cell apoptotic process [GO:0034351],
positive regulation of protein dephosphorylation [GO:0035307],
intracellular signal transduction [GO:0035556],
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096],
B cell proliferation [GO:0042100],
neutrophil activation [GO:0042119],
positive regulation of protein import into nucleus [GO:0042307],
defense response to bacterium [GO:0042742],
neutrophil degranulation [GO:0043312],
negative regulation of MAP kinase activity [GO:0043407],
regulation of mRNA stability [GO:0043488],
negative regulation of insulin receptor signaling pathway [GO:0046627],
negative regulation of inflammatory response [GO:0050728],
negative regulation of peptidyl-tyrosine phosphorylation [GO:0050732],
protein stabilization [GO:0050821],
negative regulation of filopodium assembly [GO:0051490],
cell chemotaxis [GO:0060326],
interferon-gamma-mediated signaling pathway [GO:0060333],
cellular response to hydrogen peroxide [GO:0070301],
cellular response to hydroperoxide [GO:0071447],
negative regulation of platelet aggregation [GO:0090331],
cellular senescence [GO:0090398],
positive regulation of phospholipid scramblase activity [GO:1900163],
cellular response to angiotensin [GO:1904385],
positive regulation of ceramide biosynthetic process [GO:2000304],
positive regulation of glucosylceramide catabolic process [GO:2000753],
positive regulation of sphingomyelin catabolic process [GO:2000755],
positive regulation of response to DNA damage stimulus [GO:2001022],
positive regulation of apoptotic signaling pathway [GO:2001235],
response to oxidative stress [GO:0006979],
phosphorylation [GO:0016310],
collagen metabolic process [GO:0032963],
cellular response to oxidative stress [GO:0034599],
regulation of phosphorylation [GO:0042325],
positive regulation of apoptotic process [GO:0043065],
positive regulation of MAP kinase activity [GO:0043406],
positive regulation of MAPK cascade [GO:0043410],
positive regulation of glucose import [GO:0046326],
protein autophosphorylation [GO:0046777],
D-aspartate import [GO:0070779],

Molecular Function:
protein kinase activity [GO:0004672],
protein serine/threonine kinase activity [GO:0004674],
protein kinase C activity [GO:0004697],
calcium-dependent protein kinase C activity [GO:0004698],
calcium-independent protein kinase C activity [GO:0004699],
non-membrane spanning protein tyrosine kinase activity [GO:0004715],
protein binding [GO:0005515],
ATP binding [GO:0005524],
enzyme activator activity [GO:0008047],
enzyme binding [GO:0019899],
kinase binding [GO:0019900],
protein kinase binding [GO:0019901],
insulin receptor substrate binding [GO:0043560],
metal ion binding [GO:0046872],
nucleotide binding [GO:0000166],
kinase activity [GO:0016301],
transferase activity [GO:0016740],
TIR domain binding [GO:0070976],

Cellular Component:
extracellular region [GO:0005576],
nucleus [GO:0005634],
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
endoplasmic reticulum [GO:0005783],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
cell-cell junction [GO:0005911],
nuclear matrix [GO:0016363],
azurophil granule lumen [GO:0035578],
perinuclear region of cytoplasm [GO:0048471],
extracellular exosome [GO:0070062],
mitochondrion [GO:0005739],
membrane [GO:0016020],
postsynaptic cytosol [GO:0099524],