PPP3R1

protein phosphatase 3 regulatory subunit B, alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
31945054 IMR-90 Human YES

GO terms:

Biological Process:
protein dephosphorylation [GO:0006470],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
calcineurin-NFAT signaling cascade [GO:0033173],
Fc-epsilon receptor signaling pathway [GO:0038095],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740],
patterning of blood vessels [GO:0001569],
epithelial to mesenchymal transition [GO:0001837],
protein import into nucleus [GO:0006606],
heart development [GO:0007507],
Schwann cell development [GO:0014044],
myelination in peripheral nervous system [GO:0022011],
protein localization to nucleus [GO:0034504],
lung epithelial cell differentiation [GO:0060487],

Molecular Function:
calcium-dependent protein serine/threonine phosphatase activity [GO:0004723],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
cyclosporin A binding [GO:0016018],
phosphatase binding [GO:0019902],
protein domain specific binding [GO:0019904],
phosphoprotein phosphatase activity [GO:0004721],
enzyme binding [GO:0019899],
metal ion binding [GO:0046872],

Cellular Component:
nucleoplasm [GO:0005654],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
calcineurin complex [GO:0005955],
sarcolemma [GO:0042383],
cytoplasm [GO:0005737],
plasma membrane [GO:0005886],
membrane [GO:0016020],
synapse [GO:0045202],
glutamatergic synapse [GO:0098978],