PPP3CA

protein phosphatase 3 catalytic subunit alpha

Link to human ortholog
Link to mouse ortholog

Search for interactions with genes linked to senescence.

Status in senescence: Up-regulated

Pubmed ID Cell line Tissue Source High-throughput
20485437 SCC13 Human, mouse NO

Status in senescence: Down-regulated

Pubmed ID Cell line Tissue Source High-throughput
30920150 Primary vascular progenitor cells derived from artery Human YES

GO terms:

Biological Process:
G1/S transition of mitotic cell cycle [GO:0000082],
response to amphetamine [GO:0001975],
protein dephosphorylation [GO:0006470],
protein import into nucleus [GO:0006606],
calcium ion transport [GO:0006816],
Wnt signaling pathway, calcium modulating pathway [GO:0007223],
brain development [GO:0007420],
aging [GO:0007568],
transition between fast and slow fiber [GO:0014883],
cardiac muscle hypertrophy in response to stress [GO:0014898],
dephosphorylation [GO:0016311],
positive regulation of cell migration [GO:0030335],
calcineurin-NFAT signaling cascade [GO:0033173],
multicellular organismal response to stress [GO:0033555],
negative regulation of chromatin binding [GO:0035562],
cellular response to drug [GO:0035690],
Fc-epsilon receptor signaling pathway [GO:0038095],
T cell activation [GO:0042110],
skeletal muscle tissue regeneration [GO:0043403],
positive regulation of cell adhesion [GO:0045785],
positive regulation of endocytosis [GO:0045807],
positive regulation of transcription from RNA polymerase II promoter [GO:0045944],
negative regulation of insulin secretion [GO:0046676],
skeletal muscle fiber development [GO:0048741],
negative regulation of dendrite morphogenesis [GO:0050774],
positive regulation of sequence-specific DNA binding transcription factor activity [GO:0051091],
response to calcium ion [GO:0051592],
excitatory postsynaptic potential [GO:0060079],
peptidyl-serine dephosphorylation [GO:0070262],
cellular response to glucose stimulus [GO:0071333],
calcineurin-mediated signaling [GO:0097720],
positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244],
negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799],
positive regulation of connective tissue replacement [GO:1905205],
positive regulation of cardiac muscle hypertrophy [GO:0010613],
positive regulation of gene expression [GO:0010628],
negative regulation of gene expression [GO:0010629],
calcium-mediated signaling [GO:0019722],
modulation of synaptic transmission [GO:0050804],

Molecular Function:
protein serine/threonine phosphatase activity [GO:0004722],
calcium ion binding [GO:0005509],
protein binding [GO:0005515],
calmodulin binding [GO:0005516],
drug binding [GO:0008144],
cyclosporin A binding [GO:0016018],
enzyme binding [GO:0019899],
calmodulin-dependent protein phosphatase activity [GO:0033192],
macromolecular complex binding [GO:0044877],
protein dimerization activity [GO:0046983],
ATPase binding [GO:0051117],
phosphoprotein phosphatase activity [GO:0004721],
calcium-dependent protein serine/threonine phosphatase activity [GO:0004723],
hydrolase activity [GO:0016787],
metal ion binding [GO:0046872],

Cellular Component:
nucleoplasm [GO:0005654],
cytoplasm [GO:0005737],
mitochondrion [GO:0005739],
cytosol [GO:0005829],
plasma membrane [GO:0005886],
calcineurin complex [GO:0005955],
cytoplasmic side of plasma membrane [GO:0009898],
extrinsic component of plasma membrane [GO:0019897],
Z disc [GO:0030018],
slit diaphragm [GO:0036057],
sarcolemma [GO:0042383],
dendritic spine [GO:0043197],
glutamatergic synapse [GO:0098978],
nucleus [GO:0005634],
membrane [GO:0016020],
cell junction [GO:0030054],
cell projection [GO:0042995],
synapse [GO:0045202],